Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
0.600 Biomarker disease BEFREE Striatal CB1R may contribute to the pathophysiology of WM deficits in male patients and have implications for drug development in schizophrenia. 31801965 2019
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
0.600 Biomarker disease BEFREE The most well established finding is the down-regulation of cannabinoid CB1 receptors (CB1R) after chronic and recent cannabis exposure, but it remains uncertain whether this effect is present in cannabis users with schizophrenia. 30635160 2019
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
0.600 Biomarker disease BEFREE Therefore, the endocannabinoid system could represent a therapeutic target for schizophrenia as a regulator of glutamate and GABA release via the CB1 receptor (CB1R). 31202911 2019
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
0.600 GeneticVariation disease BEFREE <b>Background:</b> Several studies have revealed significant associations between single nucleotide polymorphisms (SNPs) in the cannabinoid receptor 1 (<i>CNR1</i>) gene and a broad spectrum of psychiatric disorders such as major depressive disorder (MDD), attention deficit hyperactivity disorder (ADHD), and schizophrenia. 29963071 2018
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
0.600 AlteredExpression disease BEFREE To gain insight into this factor, we assessed the postnatal developmental trajectory of CB1R expression in the methylazoxymethanol (MAM) model of schizophrenia. 29705007 2018
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
0.600 GeneticVariation disease BEFREE The hippocampi of schizophrenia-like brains that were treated with the cannabinoid receptor-1 inverse antagonist AM251 expressed H3K9ac at the level observed in normal brains. 28300292 2018
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
0.600 GeneticVariation disease BEFREE Indeed, in several brain regions implicated in the putative neural circuitry of SZ (e.g., hippocampus, frontal cortex, cerebellum), cannabinoid receptor type 1 (CB1Rs) and glutamate N-methyl-D-aspartate receptors (NMDARs) have direct and indirect interactions. 29247465 2018
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
0.600 Biomarker disease BEFREE The present review surveys what is currently known about the interactions of CB1Rs with dopamine, serotonin, and glutamate systems, because all three of those neurotransmitters are well-established in the pathophysiology of schizophrenia and psychosis. 29385930 2018
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
0.600 GeneticVariation disease BEFREE Papers were retrieved from PubMed and ISI Web of Knowledge using the search term schizophrenia in combination with CNR1 or CB1 or cannabinoid receptor. 28099629 2017
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
0.600 AlteredExpression disease BEFREE The results point towards the hypothesis that increased CB1R levels could be a confounding effect of antipsychotic medication in schizophrenia that is circumveneted by high fat feeding. 28619471 2017
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
0.600 Biomarker disease BEFREE The involvement of CB1 receptor ligands in the schizophrenia has already been revealed and confirmed. 28138895 2017
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
0.600 Biomarker disease BEFREE Overall, our findings suggest a selective dysregulation of ECS in psychosis, and highlight the evaluation of CNR1 DNA methylation levels in PBMCs as a potential biomarker for schizophrenia. 28108228 2017
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
0.600 GeneticVariation disease BEFREE Cannabinoid receptor 1 (CNR1) gene polymorphisms have been associated with central and peripheral effects of cannabis and schizophrenia pathophysiology. 26071625 2015
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
0.600 GeneticVariation disease BEFREE In this study, although the result indicates that CNR1 and CNR2 variations are unlikely to influence schizophrenia susceptibility in a Korean population, the findings would provide meaningful information for further genetic studies. 25014618 2014
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
0.600 Biomarker disease BEFREE In either case, greater CB1R receptor availability may contribute to the increased susceptibility of schizophrenia subjects to the deleterious effects of cannabis use. 25107849 2014
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
0.600 GeneticVariation disease BEFREE In the present study, we investigated three polymorphisms (rs1049353, rs806368, and rs4707436) in the cannabinoid type 1 receptor gene (CNR1) and weight gain in Korean patients with schizophrenia receiving olanzapine treatment. 21695734 2013
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
0.600 GeneticVariation disease BEFREE We previously reported that marijuana misuse in conjunction with specific cannabinoid receptor 1 (CNR1) genetic variants (rs12720071-G-allele carriers) contributed to white-matter (WM) brain volume deficits in schizophrenia patients. 22850347 2013
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
0.600 GeneticVariation disease BEFREE These results provide evidence that the prevalence of MetS is associated with the CNR1 gene in patients with SCZ during long-term treatment with antipsychotic treatment. 23422373 2013
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
0.600 GeneticVariation disease BEFREE Seven out of the 32 tSNPs within PPARA (rs4253765, rs4263776, rs6007662, rs1800206, rs4253763, rs6008197 and rs4253655) and 3 out of 12 tSNPs within CNR1 (rs1049353, rs7766029 and rs806366) were nominally associated with SZ (uncorrected p<0.05). 22920733 2013
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
0.600 Biomarker disease BEFREE The specific binding of [(3)H]MePPEP to CB(1) receptors was 20% higher in patients with schizophrenia than in controls. 22910406 2012
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
0.600 AlteredExpression disease BEFREE The findings that reduced GAD(67) mRNA expression can induce lower CB1R mRNA expression support the hypothesis that lower cortical levels of CB1Rs in schizophrenia may partially compensate for deficient GAD(67)-mediated GABA synthesis by reducing endogenous cannabinoid suppression of GABA release. 22036037 2012
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
0.600 GeneticVariation disease BEFREE Twenty tagSNPs spanning the CNR1 gene were analyzed in schizophrenia patients of European ancestry (n=191; 74 with TD). 21266946 2012
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
0.600 Biomarker disease BEFREE No study to-date has systematically investigated the impact of CNR1 on quantitative phenotypic features in schizophrenia and inter-relationships with marijuana misuse. 21420833 2011
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
0.600 Biomarker disease CTD_human Recently, an (AAT)n triplet repeat polymorphism within the cannabinoid receptor gene CNR1 has been found to be associated with both schizophrenia and substance dependence, and to modulate the P300 potential. 21513772 2011
Entrez Id: 1268
Gene Symbol: CNR1
CNR1
0.600 GeneticVariation disease BEFREE Recently, an (AAT)n triplet repeat polymorphism within the cannabinoid receptor gene CNR1 has been found to be associated with both schizophrenia and substance dependence, and to modulate the P300 potential. 21513772 2011