Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2890
Gene Symbol: GRIA1
GRIA1
0.500 GeneticVariation disease GWASCAT Genome-Wide Association Study Detected Novel Susceptibility Genes for Schizophrenia and Shared Trans-Populations/Diseases Genetic Effect. 30285260 2019
Entrez Id: 2890
Gene Symbol: GRIA1
GRIA1
0.500 Biomarker disease BEFREE Therefore, sustained elevation of hippocampal-prefrontal theta coherence may underlie a failure in regulating novelty-related selective attention leading to aberrant salience, and thereby represents a mechanistic link between GRIA1 and schizophrenia. 31000699 2019
Entrez Id: 2890
Gene Symbol: GRIA1
GRIA1
0.500 GeneticVariation disease BEFREE Genome-wide association studies have suggested a link between schizophrenia and genes associated with synaptic plasticity, including the Gria1 gene which codes for the GluA1 subunit of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor. 30108203 2018
Entrez Id: 2890
Gene Symbol: GRIA1
GRIA1
0.500 Biomarker disease BEFREE The GluA1 AMPAR subunit (encoded by the Gria1 gene) has been implicated in schizophrenia. 28496171 2017
Entrez Id: 2890
Gene Symbol: GRIA1
GRIA1
0.500 Biomarker disease BEFREE Here, we tested the ability of LY354740 to rescue spatial working memory performance in mice that lack the GluA1 subunit of the AMPA glutamate receptor, encoded by Gria1, a gene recently implicated in schizophrenia by genome-wide association studies. 28186680 2017
Entrez Id: 2890
Gene Symbol: GRIA1
GRIA1
0.500 Biomarker disease BEFREE While GluA1 is important for cognition, it is not clear what the role of GluA1 is in hedonic responses that are relevant to the negative symptoms of disorders such as schizophrenia. 28785046 2017
Entrez Id: 2890
Gene Symbol: GRIA1
GRIA1
0.500 GeneticVariation disease GWASCAT Genome-wide association study of schizophrenia in Ashkenazi Jews. 26198764 2015
Entrez Id: 2890
Gene Symbol: GRIA1
GRIA1
0.500 GeneticVariation disease BEFREE What causes aberrant salience in schizophrenia? A role for impaired short-term habituation and the GRIA1 (GluA1) AMPA receptor subunit. 25224260 2014
Entrez Id: 2890
Gene Symbol: GRIA1
GRIA1
0.500 Biomarker disease PSYGENET A significantly increased risk of schizophrenia was associated with the A allele of rs1428920 and rs2926835 of GRIA1. 23053966 2012
Entrez Id: 2890
Gene Symbol: GRIA1
GRIA1
0.500 GeneticVariation disease BEFREE A significantly increased risk of schizophrenia was associated with the A allele of rs1428920 and rs2926835 of GRIA1. 23053966 2012
Entrez Id: 2890
Gene Symbol: GRIA1
GRIA1
0.500 GeneticVariation disease BEFREE Our findings provide no evidence for an association between SNPs within GRIA1, GRIA2 and GRIA4 under investigation and schizophrenia susceptibility, although rs3813296 (GRIA2) could be associated with improvement on PANSS negative scores. 22094384 2012
Entrez Id: 2890
Gene Symbol: GRIA1
GRIA1
0.500 Biomarker disease PSYGENET Do GluA1 knockout mice exhibit behavioral abnormalities relevant to the negative or cognitive symptoms of schizophrenia and schizoaffective disorder? 21693126 2012
Entrez Id: 2890
Gene Symbol: GRIA1
GRIA1
0.500 AlteredExpression disease BEFREE These data suggest that increased GRIA1 subunit expression may contribute to schizophrenia pathology. 17942280 2007
Entrez Id: 2890
Gene Symbol: GRIA1
GRIA1
0.500 Biomarker disease BEFREE The glutamatergic hypothesis of schizophrenia lead recently to a first successful mGlu2/3 receptor agonistic drug and is underpinned by significant findings in genes regulating the glutamatergic system (SLC1A6, SLC1A2 GRIN1, GRIN2A, GRIA1, NRG1, ErbB4, DTNBP1, DAAO, G72/30, GRM3). 17982252 2007
Entrez Id: 2890
Gene Symbol: GRIA1
GRIA1
0.500 Biomarker disease BEFREE Therefore our data indicate that GRIA1 may be involved in susceptibility to DSM-IV-TR schizophrenia. 16526023 2006
Entrez Id: 2890
Gene Symbol: GRIA1
GRIA1
0.500 Biomarker disease LHGDN Therefore our data indicate that GRIA1 may be involved in susceptibility to DSM-IV-TR schizophrenia. 16526023 2006
Entrez Id: 2890
Gene Symbol: GRIA1
GRIA1
0.500 AlteredExpression disease BEFREE To determine whether gene expression of AMPARs and/or AMPAR binding proteins, which control response/sensitivity of AMPAR-bearing neurons to glutamate, are altered in schizophrenia, mRNA expression and abundance of AMPAR subunits (GluR1-4) and several AMPAR binding proteins (SAP97, PICK1, GRIP, ABP) were measured in the dorsolateral prefrontal cortex (DLPFC) and the occipital cortex of elderly schizophrenia patients (n = 36) and matched normal controls (n = 26) by quantitative real-time PCR. 15696539 2005
Entrez Id: 2890
Gene Symbol: GRIA1
GRIA1
0.500 AlteredExpression disease BEFREE In conjunction with earlier findings of reduced hippocampal GluR1 and GluR2 expression and a loss of [3H]KA binding sites, these data show that schizophrenia is associated with impaired expression of both AMPA- and KA-preferring ionotropic glutamate receptors. 9099808 1997
Entrez Id: 2890
Gene Symbol: GRIA1
GRIA1
0.500 Biomarker disease BEFREE GluR1 and GluR2 mRNAs were less abundant per neuron in CA4 and CA3 in schizophrenia than in controls. 7609609 1995