Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2904
Gene Symbol: GRIN2B
GRIN2B
0.700 AlteredExpression disease BEFREE Using mature miRNA profiling and quantitative real-time PCR (qRT-PCR) in the orbitofrontal cortex (OFC) of SCZ (N = 29; 20 male and 9 female), BD (N = 26; 12 male and 14 female), and unaffected control (N = 25; 21 male and 4 female) subjects, we uncovered that miR-223, an exosome-secreted miRNA that targets glutamate receptors, was increased at the mature miRNA level in the OFC of SCZ and BD patients with positive history of psychosis at the time of death and was inversely associated with deficits in the expression of its targets glutamate ionotropic receptor NMDA-type subunit 2B (GRIN2B) and glutamate ionotropic receptor AMPA-type subunit 2 (GRIA2). 31775160 2020
Entrez Id: 2904
Gene Symbol: GRIN2B
GRIN2B
0.700 Biomarker disease BEFREE In a recent weighted burden analysis of exome-sequenced schizophrenia cases and controls, we noted modest statistical evidence for an enrichment of rare, functional variants in FYN, GRIN1, and GRIN2B in schizophrenia cases. 30664045 2019
Entrez Id: 2904
Gene Symbol: GRIN2B
GRIN2B
0.700 PosttranslationalModification disease BEFREE Changes in GRIN2B promoter methylation may represent an environmental influence contributing to glutamatergic dysfunction in psychosis and relate to lower cognitive performance in subjects with first-episode schizophrenia. 30785307 2019
Entrez Id: 2904
Gene Symbol: GRIN2B
GRIN2B
0.700 Biomarker disease BEFREE <i>N</i>-Methyl D-aspartate receptor subtype 2B (NR2B)-containing NMDAR are associated with cognitive dysfunction in schizophrenia. 29695955 2018
Entrez Id: 2904
Gene Symbol: GRIN2B
GRIN2B
0.700 GeneticVariation disease BEFREE We analyzed several variants located in the GluN2B C terminus and found that three variants in patients with autism (S1415L) or schizophrenia (L1424F and S1452F) (S1413L, L1422F, and S1450F in rodents, respectively) displayed impaired binding to membrane-associated guanylate kinase (MAGUK) proteins. 28283559 2017
Entrez Id: 2904
Gene Symbol: GRIN2B
GRIN2B
0.700 AlteredExpression disease BEFREE Accordingly, we found that upon crack inhalation mice have shown decreased social interaction and working memory deficits analogous to schizophrenia's symptoms, along with increased D2S/D2L expression ratio and decreased expression of NR1, NR2A and NR2B NMDA receptor subunits in the PFC. 28314129 2017
Entrez Id: 2904
Gene Symbol: GRIN2B
GRIN2B
0.700 Biomarker disease RGD The selective loss of NR2B protein and subsequent synaptic dysfunction weakens plPFC function during development and may underlie early cognitive impairments in SCZ models and patients. 28628228 2017
Entrez Id: 2904
Gene Symbol: GRIN2B
GRIN2B
0.700 Biomarker disease BEFREE The selective loss of NR2B protein and subsequent synaptic dysfunction weakens plPFC function during development and may underlie early cognitive impairments in SCZ models and patients. 28628228 2017
Entrez Id: 2904
Gene Symbol: GRIN2B
GRIN2B
0.700 GeneticVariation disease BEFREE GRIN2B variants were genotyped using standard TaqMan procedures in 175 European patients with schizophrenia deemed resistant or intolerant to treatment. 26876050 2016
Entrez Id: 2904
Gene Symbol: GRIN2B
GRIN2B
0.700 GeneticVariation disease BEFREE To further examine the association between mutations in GRIN2B and SCZ/ASD development, a larger sample size and functional experiments are needed. 27616045 2016
Entrez Id: 2904
Gene Symbol: GRIN2B
GRIN2B
0.700 GeneticVariation disease BEFREE In this study, we investigated whether single nucleotide polymorphisms (SNPs) in GRIN2B were associated with schizophrenia. 27453061 2016
Entrez Id: 2904
Gene Symbol: GRIN2B
GRIN2B
0.700 GeneticVariation disease BEFREE A surprising number of variants have been found in the N-methyl-d-aspartate receptor (NMDAR) gene family, with the GRIN2B gene encoding the GluN2B subunit being implicated in many cases of neurodevelopmental disorders, which are psychiatric conditions originating in childhood and include language, motor, and learning disorders, autism spectrum disorder (ASD), attention deficit hyperactivity disorder (ADHD), developmental delay, epilepsy, and schizophrenia. 27818011 2016
Entrez Id: 2904
Gene Symbol: GRIN2B
GRIN2B
0.700 GeneticVariation disease GWASCAT Genome-wide association study of schizophrenia in Ashkenazi Jews. 26198764 2015
Entrez Id: 2904
Gene Symbol: GRIN2B
GRIN2B
0.700 GeneticVariation disease BEFREE In this study, we performed a case-control study to identify polymorphisms of the GRIN2B gene that may confer susceptibility to SZ in the Han Chinese population. 26020650 2015
Entrez Id: 2904
Gene Symbol: GRIN2B
GRIN2B
0.700 Biomarker disease BEFREE Especially, GluN2B, a subunit of NMDA receptors, associated trafficking complex is altered in the prefrontal cortex of schizophrenia. 26421900 2015
Entrez Id: 2904
Gene Symbol: GRIN2B
GRIN2B
0.700 Biomarker disease BEFREE These findings suggest that GRIN2B may be associated with schizophrenia and interaction effects of the polymorphisms in hsa-miR-219, CAKM2G, GRIN2B and GRIN3A may confer susceptibility to schizophrenia in the Chinese Han population. 26257337 2015
Entrez Id: 2904
Gene Symbol: GRIN2B
GRIN2B
0.700 AlteredExpression disease BEFREE Genetic variation in the NR2B gene predicts reduced levels of the obligatory NR1 subunit, suggesting a novel mechanism by which the NR2B SNP may negatively influence other NMDAR subunit expression and reasoning ability in schizophrenia. 23070074 2013
Entrez Id: 2904
Gene Symbol: GRIN2B
GRIN2B
0.700 Biomarker disease BEFREE These results suggest that SLC1A1, GRIN2B, and interactions between the two may potentially confer a susceptibility to OC symptoms in schizophrenia patients receiving clozapine. 23660601 2013
Entrez Id: 2904
Gene Symbol: GRIN2B
GRIN2B
0.700 AlteredExpression disease BEFREE One possible source of compromised glutamatergic function in SZ is decreased surface expression of GluN2B-containing NMDARs. 22781170 2012
Entrez Id: 2904
Gene Symbol: GRIN2B
GRIN2B
0.700 GeneticVariation disease BEFREE The significant associations and interactions were located at the 3' region of GRIN2B suggesting that genetic variation in this part of the gene may be involved in the pathophysiology of schizophrenia. 21919190 2011
Entrez Id: 2904
Gene Symbol: GRIN2B
GRIN2B
0.700 GeneticVariation disease BEFREE Variations in the N-methyl-d-aspartate receptor 2B subunit gene (GRIN2B) have been associated with schizophrenia, a psychiatric disorder associated with reduced left-hemispheric language dominance. 21827795 2011
Entrez Id: 2904
Gene Symbol: GRIN2B
GRIN2B
0.700 GeneticVariation disease BEFREE The present results support the hypothesis that rare de novo mutations in GRIN2A or GRIN2B can be associated with cases of sporadic SCZ or ASD, just as it has recently been described for the related neurodevelopmental disease intellectual disability. 22833210 2011
Entrez Id: 2904
Gene Symbol: GRIN2B
GRIN2B
0.700 AlteredExpression disease BEFREE In the present work, we investigated whether expression of this NR2B-associated trafficking complex might be abnormal in schizophrenia. 20347576 2010
Entrez Id: 2904
Gene Symbol: GRIN2B
GRIN2B
0.700 Biomarker disease CTD_human Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database. 18583979 2008
Entrez Id: 2904
Gene Symbol: GRIN2B
GRIN2B
0.700 AlteredExpression disease BEFREE We found decreased NR1 expression in all three illnesses, decreased NR2A in schizophrenia and major depression, and decreased NR2C in schizophrenia.We found no changes of NR2B or NR2D. 18033238 2008