Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 775
Gene Symbol: CACNA1C
CACNA1C
0.500 GeneticVariation disease BEFREE CACNA1C Polymorphism (rs2283291) Is Associated with Schizophrenia in Chinese Males: A Case-Control Study. 31061683 2019
Entrez Id: 775
Gene Symbol: CACNA1C
CACNA1C
0.500 Biomarker disease BEFREE We finaly prioritized 10 target genes for schizophrenia (CACNA1C, CLU, CSNK2B, GABBR1, GRIN2A, MAPK3, NOTCH4, SRR, TNF, and SYNGAP1). 30705251 2019
Entrez Id: 775
Gene Symbol: CACNA1C
CACNA1C
0.500 Biomarker disease BEFREE Our findings provide important evidence for the establishment of CACNA1C as a susceptibility gene for schizophrenia across world populations, but its roles in the pathogenesis of schizophrenia need to be further investigated. 31033230 2019
Entrez Id: 775
Gene Symbol: CACNA1C
CACNA1C
0.500 Biomarker disease BEFREE The objective was to study the association of two genes of voltage-gated ion channels (CACNA1C and KCNH2) with the functional modulation of the cortical networks measured with EEG and graph-theory parameter during a cognitive task, both in individuals with schizophrenia and healthy controls. 30607529 2019
Entrez Id: 775
Gene Symbol: CACNA1C
CACNA1C
0.500 GeneticVariation disease GWASCAT Association of Schizophrenia Risk With Disordered Niacin Metabolism in an Indian Genome-wide Association Study. 31268507 2019
Entrez Id: 775
Gene Symbol: CACNA1C
CACNA1C
0.500 GeneticVariation disease BEFREE Associations of schizophrenia risk genes ZNF804A and CACNA1C with schizotypy and modulation of attention in healthy subjects. 31076262 2019
Entrez Id: 775
Gene Symbol: CACNA1C
CACNA1C
0.500 Biomarker disease BEFREE The risk gene CACNA1C is strongly implicated in the etiology of all major psychiatric disorders, such as depressive disorder, bipolar disorder, autism spectrum disorder, and schizophrenia. 30902660 2019
Entrez Id: 775
Gene Symbol: CACNA1C
CACNA1C
0.500 GeneticVariation disease BEFREE Genome-wide association studies have suggested that allelic variations in the CACNA1C gene confer susceptibility to schizophrenia and bipolar disorder only in women. 30124797 2019
Entrez Id: 775
Gene Symbol: CACNA1C
CACNA1C
0.500 GeneticVariation disease GWASCAT Genome-Wide Association Study Detected Novel Susceptibility Genes for Schizophrenia and Shared Trans-Populations/Diseases Genetic Effect. 30285260 2019
Entrez Id: 775
Gene Symbol: CACNA1C
CACNA1C
0.500 GeneticVariation disease GWASCAT Pleiotropic Meta-Analysis of Cognition, Education, and Schizophrenia Differentiates Roles of Early Neurodevelopmental and Adult Synaptic Pathways. 31374203 2019
Entrez Id: 775
Gene Symbol: CACNA1C
CACNA1C
0.500 GeneticVariation disease BEFREE Human genetic variation in the gene CACNA1C, which codes for the alpha-1c subunit of Cav1.2 L-type calcium channels (LTCCs), has been broadly associated with enhanced risk for neuropsychiatric disorders including major depression, bipolar and schizophrenia. 30176250 2019
Entrez Id: 775
Gene Symbol: CACNA1C
CACNA1C
0.500 GeneticVariation disease GWASCAT Bivariate genome-wide association analyses of the broad depression phenotype combined with major depressive disorder, bipolar disorder or schizophrenia reveal eight novel genetic loci for depression. 30626913 2019
Entrez Id: 775
Gene Symbol: CACNA1C
CACNA1C
0.500 AlteredExpression disease BEFREE We also found unprecedented evidence for epistasis (interaction between genetic polymorphisms) in the caudate nucleus, thalamus, and cingulate and temporal cortical activation; and CACNA1C up-regulation in SCZ and BD parietal cortices. 30079586 2019
Entrez Id: 775
Gene Symbol: CACNA1C
CACNA1C
0.500 GeneticVariation disease BEFREE Taken together, results of this study suggested that rs2007044 could affect the activation of the left IFG, which was a possible brain mechanism underlying the association between CACNA1C gene polymorphism and schizophrenia. 30268820 2019
Entrez Id: 775
Gene Symbol: CACNA1C
CACNA1C
0.500 GeneticVariation disease BEFREE These results indicate that genetic variation in CACNA1C may contribute to risk for schizophrenia and bipolar disorder by impacting behavioral flexibility, potentially through altered regulation of BDNF expression in the prefrontal cortex. 30304534 2019
Entrez Id: 775
Gene Symbol: CACNA1C
CACNA1C
0.500 GeneticVariation disease BEFREE Common and rare variants of the CACNA1C voltage-gated calcium channel gene have been associated with autism and other neurodevelopmental disorders including schizophrenia, bipolar disorder and ADHD. 31805042 2019
Entrez Id: 775
Gene Symbol: CACNA1C
CACNA1C
0.500 Biomarker disease BEFREE The CACNA1C gene is strongly implicated in the etiology of multiple major neuropsychiatric disorders, such as bipolar disorder, major depression, and schizophrenia, with cognitive deficits being a common feature. 29800644 2018
Entrez Id: 775
Gene Symbol: CACNA1C
CACNA1C
0.500 GeneticVariation disease GWASCAT Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection. 29483656 2018
Entrez Id: 775
Gene Symbol: CACNA1C
CACNA1C
0.500 GeneticVariation disease BEFREE Particular sequence variants of the 30-mer are associated with risk status at several flanking single-nucleotide polymorphisms in the third intron of CACNA1C that have previously been linked to BD and SCZ. 30100087 2018
Entrez Id: 775
Gene Symbol: CACNA1C
CACNA1C
0.500 Biomarker disease BEFREE Regulatory characterisation of the schizophrenia-associated CACNA1C proximal promoter and the potential role for the transcription factor EZH2 in schizophrenia aetiology. 29501388 2018
Entrez Id: 775
Gene Symbol: CACNA1C
CACNA1C
0.500 GeneticVariation disease BEFREE Single-nucleotide polymorphisms (SNPs) in CACNA1C, the α1C subunit of the voltage-gated L-type calcium channel Ca<sub>v</sub>1.2, rank among the most consistent and replicable genetics findings in psychiatry and have been associated with schizophrenia, bipolar disorder and major depression. 28696432 2018
Entrez Id: 775
Gene Symbol: CACNA1C
CACNA1C
0.500 GeneticVariation disease GWASCAT Five novel loci associated with antipsychotic treatment response in patients with schizophrenia: a genome-wide association study. 29503163 2018
Entrez Id: 775
Gene Symbol: CACNA1C
CACNA1C
0.500 GeneticVariation disease GWASCAT Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia. 28540026 2017
Entrez Id: 775
Gene Symbol: CACNA1C
CACNA1C
0.500 GeneticVariation disease BEFREE Put in perspective, ZNF804A rs1344706, not only had a significant main effect, but its SZ-specific effects were two orders of magnitude more widespread than that of CACNA1C rs1006737. 27790829 2017
Entrez Id: 775
Gene Symbol: CACNA1C
CACNA1C
0.500 Biomarker disease BEFREE In humans, CACNA1C has emerged as one of the most widely reproduced and prominent candidate risk genes for a range of neuropsychiatric disorders, including bipolar disorder (BD), schizophrenia (SCZ), major depressive disorder, autism spectrum disorder, and attention deficit hyperactivity disorder. 28497380 2017