Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1278
Gene Symbol: COL1A2
COL1A2
0.400 AlteredExpression disease BEFREE Elevated pro alpha 2(I) collagen mRNA levels in cultured scleroderma fibroblasts result from an increased transcription rate of the corresponding gene. 3582658 1987
Entrez Id: 1278
Gene Symbol: COL1A2
COL1A2
0.400 AlteredExpression disease BEFREE Full thickness biopsies of affected skin and fascia from one patient with diffuse fasciitis and eosinophilia (DF), two patients with generalized morphea (GM), and five patients with progressive systemic sclerosis (PSS) of recent onset were examined for the expression of transforming growth factor beta 1 (TGF beta 1) and type I procollagen genes by in situ hybridization with human sequence-specific cDNA. 2307855 1990
Entrez Id: 1278
Gene Symbol: COL1A2
COL1A2
0.400 AlteredExpression disease BEFREE Analysis of the expression of COL1A2 promoter deletion constructs indicates that the TGF beta responsive element functional in normal fibroblasts and the sequence involved in intrinsic upregulation of COL1A2 gene expression in scleroderma fibroblasts are both located between bp-376 (Bgl II) and bp-108 (Sma I) sites. 1520334 1992
Entrez Id: 1278
Gene Symbol: COL1A2
COL1A2
0.400 AlteredExpression disease BEFREE CI secretion and steady-state pro alpha1(I) collagen messenger RNA (mRNA) levels and COL1A2 gene activation were examined in fibroblasts grown from lung biopsy specimens obtained from 16 scleroderma patients with lung fibrosis and from 10 histologically normal lung specimens (controls). 9214423 1997
Entrez Id: 1278
Gene Symbol: COL1A2
COL1A2
0.400 Biomarker disease BEFREE These results indicate that HSP47 expression is closely associated with that of type I procollagen in skin fibroblasts, and that increased expression of HSP47 may be involved in the abundant production of type I procollagen by SSc fibroblasts. 9856811 1998
Entrez Id: 1278
Gene Symbol: COL1A2
COL1A2
0.400 Biomarker disease BEFREE To investigate the disease-susceptible gene for SSc, we examined the association of the disease with a gene (COL1A2) for type I collagen, which accumulates excessively in the affected organs. 10872800 2000
Entrez Id: 1278
Gene Symbol: COL1A2
COL1A2
0.400 AlteredExpression disease BEFREE These include the role of transforming growth factor-beta (TGF-beta) and connective tissue growth factor (CTGF) and their receptors in the fibrotic process in scleroderma and the overview of the transcription factors involved in regulation of the human alpha2 (I) collagen (COL1A2) gene. 11861221 2002
Entrez Id: 1278
Gene Symbol: COL1A2
COL1A2
0.400 AlteredExpression disease BEFREE Here, we investigated the role of phosphatidylinositol 3-kinase (PI3K) in the COL1A2 gene expression in normal and scleroderma fibroblasts. 15153536 2004
Entrez Id: 1278
Gene Symbol: COL1A2
COL1A2
0.400 AlteredExpression disease BEFREE HGF did not change the protein expression of type I procollagen in the medium of normal human fibroblasts, whereas it reduced the expression in scleroderma fibroblasts. 15675950 2005
Entrez Id: 1278
Gene Symbol: COL1A2
COL1A2
0.400 AlteredExpression disease BEFREE Normal fibroblasts incubated with serum from an SSc-affected patient or with serum from her unaffected MZ twin sister developed the increased expression of COL1A2, SPARC, and CTGF typically seen in SSc fibroblasts. 16200604 2005
Entrez Id: 1278
Gene Symbol: COL1A2
COL1A2
0.400 AlteredExpression disease BEFREE However, neither Smad2 nor Smad4 caused significant effects in COL1A2 promoter activity in normal fibroblasts or SSc fibroblasts. 16319104 2006
Entrez Id: 1278
Gene Symbol: COL1A2
COL1A2
0.400 AlteredExpression disease BEFREE We have investigated the role of hc-Krox transcription factor on type I collagen expression by human dermal fibroblasts. hc-Krox exerted a stimulating effect on type I collagen protein synthesis and enhanced the corresponding mRNA steady-state levels of COL1A1 and COL1A2 in foreskin fibroblasts (FF), adult normal fibroblasts (ANF), and scleroderma fibroblasts (SF). 17698844 2007
Entrez Id: 1278
Gene Symbol: COL1A2
COL1A2
0.400 Biomarker disease LHGDN Akt blockade downregulates collagen and upregulates MMP1 in human dermal fibroblasts. 18323784 2008
Entrez Id: 1278
Gene Symbol: COL1A2
COL1A2
0.400 AlteredExpression disease BEFREE Here, we demonstrate for the first time that CS and CSf exert an inhibitory effect on type I collagen protein synthesis and decrease the corresponding mRNA steady-state levels of COL1A1 and COL1A2 in NF and SF. 18298657 2008
Entrez Id: 1278
Gene Symbol: COL1A2
COL1A2
0.400 Biomarker disease BEFREE Three orthologues of genes implicated in human SSc are located in the QTL region on chromosome 2, TGFRB1, EXOC2-IRF4 and COL1A2, as well as CCR8, which is more generally related to immune function. 22796227 2012
Entrez Id: 1278
Gene Symbol: COL1A2
COL1A2
0.400 AlteredExpression disease BEFREE Our results suggest that γ/δ T cells showed activated phenotype in SSc and suggest that SSc γ/δ T cells may play an important role on fibrotic process by upregulation of COL1A2 mRNA expression in fibroblasts. 23159281 2013
Entrez Id: 1278
Gene Symbol: COL1A2
COL1A2
0.400 AlteredExpression disease BEFREE Importantly, the inhibitory and stimulatory effects of rapamycin on the mRNA levels of COL1A2 and MMP1 genes, respectively, were significantly greater in SSc dermal fibroblasts than in normal dermal fibroblasts. 24630239 2014
Entrez Id: 1278
Gene Symbol: COL1A2
COL1A2
0.400 Biomarker disease CTD_human Targeting the myofibroblast genetic switch: inhibitors of myocardin-related transcription factor/serum response factor-regulated gene transcription prevent fibrosis in a murine model of skin injury. 24706986 2014
Entrez Id: 1278
Gene Symbol: COL1A2
COL1A2
0.400 Biomarker disease BEFREE A novel small-molecule inhibitor of MRTF/SRF-regulated transcription (CCG-203971) inhibits expression of connective tissue growth factor (CTGF), α-smooth muscle actin (α-SMA), and collagen 1 (COL1A2) in both SSc fibroblasts and in lysophosphatidic acid (LPA)-and transforming growth factor β (TGFβ)-stimulated fibroblasts. 24706986 2014