Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 9863
Gene Symbol: MAGI2
MAGI2
0.010 Biomarker disease BEFREE SScAM occurred at a median [interquartile range (IQR)] time of 1 month [0-15] after SSc diagnosis. 31734403 2020
Entrez Id: 6370
Gene Symbol: CCL25
CCL25
0.010 Biomarker disease BEFREE CCR9 + T helper (Th) cells can induce Sjögren-like symptoms in mice and both CCR9 + Th cells and their ligand CCL25 are increased in the salivary glands of primary Sjögren's syndrome (pSS) patients. 31733111 2020
Entrez Id: 633
Gene Symbol: BGN
BGN
0.010 Biomarker disease BEFREE Citrullinated vimentin and biglycan protein fingerprints as candidate serological biomarkers for disease activity in systemic sclerosis: a pilot study. 30457356 2019
Entrez Id: 213
Gene Symbol: ALB
ALB
0.010 Biomarker disease BEFREE Treatment with exogenous factors, gelatin-1, FAM20A and human albumin, which were identified from the conditioned medium of SSc fibroblasts, was important for regulating the differentiation of fibroblasts with higher levels of SOCE and α-SMA. 30870448 2019
Entrez Id: 5879
Gene Symbol: RAC1
RAC1
0.010 AlteredExpression disease BEFREE A total of 26 of these miRNAs targeted genes involved in pathways connected to the three main features of SSc and to cancer development including Epidermal growth factor (EGF) receptor, ErbB1 downstream, Sphingosine 1 phosphate receptor 1 (S1P1), Activin receptor-like kinase 1 (ALK1), Endothelins, Ras homolog family member A (RhoA), Class I Phosphoinositide 3-kinase (PI3K), mammalian target of rapamycin (mTOR), p38 mitogen-activated protein kinase (MAPK), Ras-related C3 botulinum toxin substrate 1 (RAC1), Transforming growth factor (TGF)-beta receptor, Myeloid differentiation primary response 88 (MyD88) and Toll-like receptors (TLRs) pathways. 30866419 2019
Entrez Id: 55764
Gene Symbol: IFT122
IFT122
0.010 Biomarker disease BEFREE Facile fabrication of PEG-coated PLGA microspheres via SPG membrane emulsification for the treatment of scleroderma by ECM degrading enzymes. 31005740 2019
Entrez Id: 6863
Gene Symbol: TAC1
TAC1
0.010 Biomarker disease BEFREE The objective of this case report is to highlight the potential use of a substance P antagonist in the treatment of scleroderma associated nausea. 31119781 2019
Entrez Id: 25987
Gene Symbol: TSKU
TSKU
0.010 GeneticVariation disease BEFREE In a mouse model of bleomycin-induced fibrosis (n = 5-8) and in a TSK mouse model (a genetic model of SSc) (n = 5-10), deficient expression of MFG-E8 significantly enhanced both pulmonary and skin fibrosis, and administration of rMFG-E8 significantly inhibited bleomycin-induced dermal fibrosis. 30175895 2019
Entrez Id: 653361
Gene Symbol: NCF1
NCF1
0.010 GeneticVariation disease BEFREE Association of NCF1 polymorphism with systemic lupus erythematosus and systemic sclerosis but not with ANCA-associated vasculitis in a Japanese population. 31705128 2019
Entrez Id: 284
Gene Symbol: ANGPT1
ANGPT1
0.010 Biomarker disease BEFREE Serum concentrations of Ang1 were significantly lower [mean (S.D.): 21516.04 (11,441.035) pg/ml], and Ang2 significantly increased [25,89.55 (934.225) pg/ml] in SSc as compared with the control group [Ang1: 28,457.08 (10,431.905) pg/ml; Ang2: 1556.23 (481.255) pg/ml, p < 0.01, respectively], whereas VEGF did not differ significantly. 31075243 2019
Entrez Id: 6369
Gene Symbol: CCL24
CCL24
0.010 AlteredExpression disease BEFREE Blockade of CCL24 with CM-101 significantly reduced the activation of dermal fibroblasts and their transition to myofibroblasts induced by SSc serum. 31129606 2019
Entrez Id: 50964
Gene Symbol: SOST
SOST
0.010 AlteredExpression disease BEFREE In subgroup analysis, patients with higher modified Rodnan skin score (mRodnan) had higher DKK-1, sclerostin, and TRAIL levels (<i>p</i> < 0.05); those with diffuse SSc subtype had lower BMD values than those with limited SSc (<i>p</i> < 0.05). 30001654 2019
Entrez Id: 59307
Gene Symbol: SIGIRR
SIGIRR
0.010 Biomarker disease BEFREE Emerging diversity and abundance of the innate signature in RA patients were detected: RA was characterized by the upregulation of <i>TLR3</i>, <i>TLR5</i>, <i>IL1RAP/IL1R3</i>, <i>IL18R1</i>, and <i>SIGIRR/IL1R8</i> when compared to SSc (<i>P</i><sub>corr</sub> < 0.02) and of <i>TLR2</i>, <i>TLR5</i>, and <i>SIGIRR/IL1R8</i> when compared to SLE (<i>P</i><sub>corr</sub> < 0.02). 31396542 2019
Entrez Id: 6277
Gene Symbol: S100A6
S100A6
0.010 Biomarker disease BEFREE Bronchoalveolar lavage proteomic analysis in pulmonary fibrosis associated with systemic sclerosis: S100A6 and 14-3-3ε as potential biomarkers. 30239835 2019
Entrez Id: 407017
Gene Symbol: MIR26B
MIR26B
0.010 Biomarker disease BEFREE Moreover, we demonstrated that the hsa-miR-26b-5p inhibitor might inhibit fibrosis in TGF-β-activated fibroblasts, which would be a promising target for SSc therapy. 31347003 2019
Entrez Id: 7098
Gene Symbol: TLR3
TLR3
0.010 GeneticVariation disease BEFREE The purpose of this study was to investigate whether single nucleotide polymorphisms (SNPs) of TLR2, TLR3, TLR4 and TLR9 genes are associated with susceptibility to presumed viral-induced anterior uveitis (PVIAU) and Posner-Schlossman syndrome (PSS). 31465768 2019
Entrez Id: 23591
Gene Symbol: FAM215A
FAM215A
0.010 AlteredExpression disease BEFREE Overexpression of apoptosis-related protein, survivin, in fibroblasts from patients with systemic sclerosis. 30761457 2019
Entrez Id: 6899
Gene Symbol: TBX1
TBX1
0.010 AlteredExpression disease BEFREE Furthermore, brachyury levels were significantly increased in skin samples of SSc patients relative to healthy controls. 31625918 2019
Entrez Id: 28982
Gene Symbol: FLVCR1
FLVCR1
0.010 Biomarker disease BEFREE There was no significant difference between SSc patients and controls regarding either PI or MFV of the anterior, middle, and posterior cerebral arteries; also, there was no difference regarding the third ventricle diameter; however, limited SSc patients showed a significant increase in the PI of PCA and MFV of ACA as compared with diffuse SSc patients (p = 0.005, 0.004). 30806858 2019
Entrez Id: 2549
Gene Symbol: GAB1
GAB1
0.010 AlteredExpression disease BEFREE Increased expression of GAB1 promotes inflammation and fibrosis in systemic sclerosis. 31505074 2019
Entrez Id: 10927
Gene Symbol: SPIN1
SPIN1
0.010 GeneticVariation disease BEFREE Scleroderma Patient-centered Intervention Network-Scleroderma Support group Leader EDucation (SPIN-SSLED) program: non-randomised feasibility trial. 31719073 2019
Entrez Id: 8828
Gene Symbol: NRP2
NRP2
0.010 AlteredExpression disease BEFREE Treatment with SSc serum resulted in a significant downregulation of both VEGFR-3/Flt-4 and NRP-2 mRNA and protein levels. 31817940 2019
Entrez Id: 23531
Gene Symbol: MMD
MMD
0.010 Biomarker disease BEFREE Unilateral MMD was more likely to be associated with SSc. 31812345 2019
Entrez Id: 6373
Gene Symbol: CXCL11
CXCL11
0.010 Biomarker disease BEFREE Remarkably, induction of CXCL10 and CXCL11, two IFN-related chemokines associated with SSc pathogenesis, was reduced in NRIR-knockdown monocytes, while their plasmatic level was increased in SSc patients. 30804934 2019
Entrez Id: 3556
Gene Symbol: IL1RAP
IL1RAP
0.010 Biomarker disease BEFREE Applying the association rule analysis, six rules (combinations and expression of genes describing disease) were identified for RA (most frequently included high <i>TLR3</i> and/or <i>IL1RAP/IL1R3</i>) and three rules for SLE (low <i>IL1RN</i> and <i>IL18R1</i>) and SSc (low <i>TLR5</i> and <i>IL18R1</i>). 31396542 2019