| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.330 | AlteredExpression | disease | BEFREE | Cellular SIRT1 levels were suppressed in normal fibroblasts exposed to hypoxia or platelet-derived growth factor and were constitutively down-regulated in SSc fibroblasts. | 25707573 | 2015 | ||||
|
0.330 | Therapeutic | disease | CTD_human | The Histone Deacetylase Sirtuin 1 Is Reduced in Systemic Sclerosis and Abrogates Fibrotic Responses by Targeting Transforming Growth Factor β Signaling. | 25707573 | 2015 | ||||
|
0.330 | AlteredExpression | disease | BEFREE | Sirt1, activated by resveratrol (Res), ameliorated cutaneous inflammation and fibrosis in bleomycin (BLM)-induced scleroderma mice. | 28532580 | 2017 | ||||
|
0.330 | Biomarker | disease | BEFREE | Thus, SIRT1 may be a promising therapeutic target in the management of SSc-related pulmonary fibrosis. | 28800254 | 2018 |