| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.250 | Biomarker | disease | MGD | |||||||
|
0.250 | AlteredExpression | disease | BEFREE | Our data suggest that some of the key profibrotic features of lesional SSc fibroblasts are dependent upon ALK-5 activity. | 16575856 | 2006 | ||||
|
0.250 | AlteredExpression | disease | BEFREE | Increased levels of transforming growth factor beta receptor type I and up-regulation of matrix gene program: A model of scleroderma. | 16947635 | 2006 | ||||
|
0.250 | AlteredExpression | disease | LHGDN | Increased levels of transforming growth factor beta receptor type I and up-regulation of matrix gene program: A model of scleroderma. | 16947635 | 2006 | ||||
|
0.250 | AlteredExpression | disease | BEFREE | The present study utilized previously a described model of scleroderma (SSc) fibrosis based on forced expression of the TGF-betaRI (ALK5) (Pannu, J., Gardner, H., Shearstone, J. R., Smith, E., and Trojanowska, M. (2006) Arthritis Rheum.54, 3011-3021). | 17317656 | 2007 | ||||
|
0.250 | AlteredExpression | disease | BEFREE | There was no significant difference in Smurf1 and Smurf2 levels between normal and scleroderma fibroblasts, and the transiently overexpressed Smurf1 and/or Smurf2 did not affect TGF-beta receptor type I protein levels in scleroderma fibroblasts. | 14722617 | 2004 | ||||
|
0.250 | Biomarker | disease | BEFREE | An increased transforming growth factor beta receptor type I:type II ratio contributes to elevated collagen protein synthesis that is resistant to inhibition via a kinase-deficient transforming growth factor beta receptor type II in scleroderma. | 15146427 | 2004 |