Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
0.170 | Biomarker | disease | BEFREE | We also started treatment with riociguat because we speculated she had a component of SSc-PAH and that immunosuppressive therapy alone may be insufficient. | 31183306 | 2019 | ||||
|
0.170 | GeneticVariation | disease | BEFREE | Patients with pulmonary arterial hypertension associated with connective tissue disease (PAH-PAH-CTD) such as systemic sclerosis (SSc) have a poorer response to treatment and increased mortality compared with patients with idiopathic PAH. | 28671485 | 2019 | ||||
|
0.170 | Biomarker | disease | BEFREE | Twenty-nine patients (31.2%) had RHC-proven PH; of those 29 patients, 24.1% had PAH, 55.2% had World Health Organization (WHO) Group III PH, 34.5% had WHO Group III PH with pulmonary vascular resistance >3.0 Wood units, 48.3% had a PH diagnosis within 7 years of SSc onset, 82.8% received therapy for ILD, and 82.8% received therapy for PAH. | 30762947 | 2019 | ||||
|
0.170 | GeneticVariation | disease | BEFREE | Among conventional risk factors for PAH, decreased DLCO may predict mPAP > 20 mmHg with priority in SSc patients. | 31280357 | 2019 | ||||
|
0.170 | Biomarker | disease | BEFREE | In this cross-sectional study, four groups were selected from the Australian Scleroderma Cohort Study: group 1 (n = 15) had definite PAH; group 2 (n = 19) had interstitial lung disease (ILD); group 3 (n = 30) were SSc-controls; and group 4 (n = 34) were healthy controls. | 29687288 | 2018 | ||||
|
0.170 | Biomarker | disease | BEFREE | This was a post hoc analysis of patients with CTD-PAH and SSc-PAH from AMBITION, an event-driven, double-blind trial in patients with WHO functional class II/III PAH. | 28039187 | 2017 | ||||
|
0.170 | Biomarker | disease | BEFREE | The sensitivity and specificity for SSc-PAH detection using baseline BNP≥64 pg/mL was 71% and 59%; and for NT-proBNP≥210 pg/mL, 73% and 78%. | 27908301 | 2017 | ||||
|
0.170 | Biomarker | disease | HPO |