Emerging diversity and abundance of the innate signature in RA patients were detected: RA was characterized by the upregulation of <i>TLR3</i>, <i>TLR5</i>, <i>IL1RAP/IL1R3</i>, <i>IL18R1</i>, and <i>SIGIRR/IL1R8</i> when compared to SSc (<i>P</i><sub>corr</sub> < 0.02) and of <i>TLR2</i>, <i>TLR5</i>, and <i>SIGIRR/IL1R8</i> when compared to SLE (<i>P</i><sub>corr</sub> < 0.02).