Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 919
Gene Symbol: CD247
CD247
0.460 GeneticVariation disease GWASCAT GWAS for systemic sclerosis identifies multiple risk loci and highlights fibrotic and vasculopathy pathways. 31672989 2019
Entrez Id: 919
Gene Symbol: CD247
CD247
0.460 GeneticVariation disease BEFREE Among these genes, IRF5, STAT4, and CD247 were replicated most frequently while SNPs rs35677470 in DNASE1L3, rs5029939 in TNFAIP3, and rs7574685 in STAT4 have the strongest associations with SSc. 28526340 2017
Entrez Id: 919
Gene Symbol: CD247
CD247
0.460 GeneticVariation disease BEFREE Our results suggest that genetic variants of CD226 and CD247 genes may not be a contributing factor in pathogenesis of SSc in Iranian population. 29338153 2017
Entrez Id: 919
Gene Symbol: CD247
CD247
0.460 GeneticVariation disease BEFREE Among eight SSc-associated susceptibility polymorphisms which were applied for meta-analysis, IRF5 rs2004640 polymorphism (OR 1.12; 95% CI 1.02-1.22, P = 1.39 × 10<sup>-2</sup>), STAT4 rs7574865 polymorphism (OR 1.25; 95% CI 1.07-1.47, P = 5.3 × 10<sup>-3</sup>), IRAK1 rs1059702 polymorphism (OR 1.20; 95% CI 1.05-1.37, P = 0.007), and CTGF G-945C polymorphism (OR 1.42; 95% CI 1.18-1.71, P = 0.002) are associated with PF status in SSc, while TNFAIP3 rs5029939, CD226 rs763361, CD247 rs2056626, and IRF5 rs10488631 polymorphisms are not. 28434122 2017
Entrez Id: 919
Gene Symbol: CD247
CD247
0.460 GeneticVariation disease BEFREE Five single nucleotide polymorphisms, IRF5 (rs10488631, rs12537284, rs4728142), STAT4 (rs3821236), CD247 (rs2056626) reached genome-wide significance in the SSc-GWAS and were examined in the current study. 22440820 2012
Entrez Id: 919
Gene Symbol: CD247
CD247
0.460 GeneticVariation disease GWASDB Genome-wide scan identifies TNIP1, PSORS1C1, and RHOB as novel risk loci for systemic sclerosis. 21750679 2011
Entrez Id: 919
Gene Symbol: CD247
CD247
0.460 GeneticVariation disease GWASCAT Genome-wide scan identifies TNIP1, PSORS1C1, and RHOB as novel risk loci for systemic sclerosis. 21750679 2011
Entrez Id: 919
Gene Symbol: CD247
CD247
0.460 GeneticVariation disease GWASDB Genome-wide association study of systemic sclerosis identifies CD247 as a new susceptibility locus. 20383147 2010
Entrez Id: 919
Gene Symbol: CD247
CD247
0.460 GeneticVariation disease BEFREE Analysis of 279,621 autosomal SNPs followed by replication testing in an independent case-control set of European ancestry (2,753 individuals with SSc (cases) and 4,569 controls) identified a new susceptibility locus for systemic sclerosis at CD247 (1q22-23, rs2056626, P = 2.09 x 10(-7) in the discovery samples, P = 3.39 x 10(-9) in the combined analysis). 20383147 2010
Entrez Id: 919
Gene Symbol: CD247
CD247
0.460 GeneticVariation disease GWASCAT Genome-wide association study of systemic sclerosis identifies CD247 as a new susceptibility locus. 20383147 2010
Entrez Id: 919
Gene Symbol: CD247
CD247
0.460 Biomarker disease CTD_human Genome-wide association study of systemic sclerosis identifies CD247 as a new susceptibility locus. 20383147 2010
Entrez Id: 919
Gene Symbol: CD247
CD247
0.460 AlteredExpression disease BEFREE We demonstrated that protein expression of the TCR zeta chain was significantly decreased in peripheral T cells from patients with SLE compared to normal controls and patients with systemic sclerosis (SSc). 9701029 1998