Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
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0.370 | Biomarker | phenotype | BEFREE | These studies suggest that SCB-elicited convulsions are mediated by high intrinsic efficacy at CB1Rs and that benzodiazepines may not be effective treatments. | 30420360 | 2019 | ||||
|
0.370 | Biomarker | phenotype | BEFREE | The observed changes in CB1R binding may reflect a combination of a protective mechanism of neurons against seizure activity that becomes stronger over time to combat more severe seizures, and on the other hand, a process of epileptogenesis that facilitates seizure activity and generalization, depending on the cell type involved in those specific regions. | 29663353 | 2018 | ||||
|
0.370 | Biomarker | phenotype | BEFREE | Arvanil, olvanil, AM 1172 and LY 2183240 (various cannabinoid CB1 receptor agonists) increase the threshold for maximal electroshock-induced seizures in mice. | 29335158 | 2018 | ||||
|
0.370 | AlteredExpression | phenotype | BEFREE | Obtained results showed that activation of overexpressed cannabinoid CB1 receptors by endogenous cannabinoids may have a role in mediating the inhibitory effect of LFS on perforant path kindled seizures. | 29800824 | 2018 | ||||
|
0.370 | AlteredExpression | phenotype | BEFREE | The selective activation of cannabinoid CB1 receptor-mediated neurotransmission in the brain may enhance levetiracetam-related suppression of seizures in epilepsy patients, contributing to the efficacious treatment of epilepsy in future. | 28859122 | 2017 | ||||
|
0.370 | Biomarker | phenotype | BEFREE | Also, there is no data regarding the effect of co-administration of cannabinoid type 1 (CB1) receptor agonists and BK channels antagonists in the acute models of seizure in mice. | 28979317 | 2017 | ||||
|
0.370 | Biomarker | phenotype | BEFREE | CB1 (Cnr1) and CB2 (Cnr2) single-knockout mice have been generated, with the former showing heightened seizure sensitivity, but not overt seizures. | 29105060 | 2017 | ||||
|
0.370 | Biomarker | phenotype | CTD_human | By demonstrating a role for the endogenous cannabinoid system in regulating seizure activity, these studies define a role for the endogenous cannabinoid system in modulating neuroexcitation and suggest that plasticity of the CB1 receptor occurs with epilepsy. | 12954810 | 2003 |