| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.320 | Biomarker | phenotype | BEFREE | Similarly, chemogenetic activation of CRH neurons in the paraventricular nucleus (PVN) is sufficient to increase seizure susceptibility; whereas, chemogenetic inhibition of CRH neurons in the PVN of the hypothalamus is sufficient to decrease seizure susceptibility and depression-like behaviors in chronically epileptic mice. | 29186699 | 2018 | ||||
|
0.320 | Biomarker | phenotype | BEFREE | The stress theory of spasms yielded the corticotropin releasing hormone (CRH)-induced model, which showed the higher proconvulsant potency of CRH in developing rats, although only limbic seizures were observed. | 23312951 | 2013 | ||||
|
0.320 | Biomarker | phenotype | CTD_human | The increase in GAT-1-ir somata in the CRH model and not in the hyperthermia model may reflect the difference in the duration of seizures. | 11074187 | 2000 | ||||
|
0.320 | Biomarker | phenotype | CTD_human | C-fos expression after icv CRF has been considered a useful tool in mapping areas involved in stress and in seizure activity. | 8923670 | 1996 | ||||
|
0.320 | Biomarker | phenotype | CTD_human | Administration of CRH, an age-specific endogenous convulsant, resulted in a prolonged series of seizures after 2- to 55-min latency. | 7821275 | 1995 | ||||
|
0.320 | Biomarker | phenotype | CTD_human | Corticotropin-releasing hormone-induced electrographic and behavioral seizures originate in the amygdala. | 1596084 | 1992 | ||||
|
0.320 | Biomarker | phenotype | CTD_human | When some gamma-endorphin derivatives (DT gamma E, DE gamma E) were injected intravenously (i.v.) for 4 days (or hydrocortisone once), they prevented the EEG ictal seizures induced in the hippocampus of rabbits by CRF injected i.c.v. | 1700951 | 1991 | ||||
|
0.320 | Biomarker | phenotype | CTD_human | CRH-induced seizures occurred prior to any changes in serum corticosterone, and were eliminated by the administration of a CRH antagonist, as well as of phenytoin. | 1914160 | 1991 |