| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.070 | AlteredExpression | phenotype | BEFREE | Furthermore, we found a positive correlation between miR-146a expression with seizure frequency (r = 0.803) and a positive correlation between miR-146a and 451 expression with number of antiepileptic drugs used for presurgical treatment (r = 0.715 and 0.611 respectively), thus suggesting a positive correlation with disease severity. | 31470144 | 2019 | ||||
|
0.070 | Biomarker | phenotype | BEFREE | In the miR-146a antagomir injection group, the latency to generalized convulsions was shorter, the duration and degree of seizures were more severe, the expression level of miR-146a was clearly decreased, and IL-1β, TNF-α, TLR4 and NF-κB were all significantly up-regulated. | 29144992 | 2018 | ||||
|
0.070 | Biomarker | phenotype | BEFREE | This study is the first to demonstrate that intranasal delivery of miR-146a mimics can improve seizure onset and hippocampal damage in the acute phase of lithium-pilocarpine-induced seizures, which provides inflammation-based clues for the development of novel TLE treatments. | 28242958 | 2017 | ||||
|
0.070 | GeneticVariation | phenotype | BEFREE | miR-146a rs57095329 polymorphism might be involved in the genetic susceptibility to drug-resistance and seizure severity in childhood epilepsy patients. | 27310665 | 2016 | ||||
|
0.070 | AlteredExpression | phenotype | BEFREE | Down-regulating miR-146a by intracerebroventricular injection of antagomir-146a enhanced the hippocampal expression of CFH in TLE model and decreased seizure susceptibility. | 27852797 | 2016 | ||||
|
0.070 | AlteredExpression | phenotype | BEFREE | Tumor and peritumoral miR146a expression was negatively correlated with frequency of seizures and the density of activated microglial cells. | 25986346 | 2015 | ||||
|
0.070 | Biomarker | phenotype | BEFREE | Recently, a growing body of evidence has suggested that microRNA-146a (miR-146a) is upregulated in the brains of epilepsy patients and of mouse models; furthermore, miR-146a may be involved in the development and progression of seizures through the regulation of inflammation and immune responses. | 25891929 | 2015 |