Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5460
Gene Symbol: POU5F1
POU5F1
0.060 Biomarker disease BEFREE In seminoma we observed that tumor cells strongly express OCT-4 in all seminomas and in the intratubular areas of seminoma. 31572301 2019
Entrez Id: 5460
Gene Symbol: POU5F1
POU5F1
0.060 Biomarker disease BEFREE Strikingly, these compounds inhibited the proliferation of pluripotent cancer cells including teratocarcinoma, embryonic carcinoma, and seminoma or embryonic stem cells that express the stem cell markers Oct4 and Sox2 while displaying minimum growth-inhibitory effects on non-pluripotent cancer or normal somatic cells. 21975933 2011
Entrez Id: 5460
Gene Symbol: POU5F1
POU5F1
0.060 AlteredExpression disease BEFREE However, protein expression of OCT3/4 and AP2y was weak and these JKT-1 cells expressed SOX2, a marker of embryonal carcinoma and did not express c-KIT usually expressed in most seminoma. 19226408 2010
Entrez Id: 5460
Gene Symbol: POU5F1
POU5F1
0.060 Biomarker disease BEFREE The intense staining pattern of OCT4 and the high sensitivity of FISH make them superior to other auxiliary diagnostic utilities for detecting seminoma. 18162782 2008
Entrez Id: 5460
Gene Symbol: POU5F1
POU5F1
0.060 Biomarker disease LHGDN The aberrant expression and distribution of the OCT-4 transcription factor in seminomas may provide some important clues concerning the cell transformation between germ line stem cells (like PGC) and testicular germ cell tumors. 17682839 2007
Entrez Id: 5460
Gene Symbol: POU5F1
POU5F1
0.060 Biomarker disease BEFREE To determine a possible role of the OCT-4 protein in seminomas, in this paper, we studied a series of 41 testicular tumor tissues and four cell lines by immunohistochemistry, Western blotting, and reverse-transcriptase polymerase chain reaction (RT-PCR) to examine the expression and distribution of the OCT-4 transcription factor in seminomas. 17682839 2007
Entrez Id: 5460
Gene Symbol: POU5F1
POU5F1
0.060 Biomarker disease BEFREE At the protein level, expression of the immunohistochemical markers cytokeratins (pan-cytokeratin staining), placental-like alkaline phosphatase, anti-cytokeratin clone 5.2, CD30, anion exchanger 1/3, junction plakoglobulin (JUP), and POU domain, class 5, transcription factor 1 (octomer-binding transcription factor 3/4) was significantly different between seminomas and embryonal tumors. 16115909 2005