| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.080 | GeneticVariation | disease | BEFREE | This study aims to determine whether preadmission antihypertensive drug use, especially angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs), is associated with decreased total hospital mortality in sepsis. | 31135703 | 2020 | ||||
|
0.080 | Biomarker | disease | BEFREE | Although ACE is known to contribute to damage in septicemia, the pathophysiological mechanisms of sepsis remain unclear. | 31733315 | 2020 | ||||
|
0.080 | Biomarker | disease | BEFREE | The occurrence rate of sepsis was 3.67 per 100 person-years for the patients receiving angiotensin-converting enzyme inhibitors and 2.87 per 100 person-years for those receiving angiotensin receptor blockers. | 30303835 | 2019 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | Our meta-analysis confirmed that the angiotensin-converting enzyme I/D polymorphism was associated with sepsis risk. | 23748624 | 2015 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | The statistical data suggest that the CD143 gene ins/del polymorphism may influence the risk of sepsis, especially pediatric sepsis. | 25400733 | 2014 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | Angiotensin-converting enzyme insertion/deletion polymorphism is not associated with susceptibility and outcome in sepsis and acute respiratory distress syndrome. | 18060663 | 2008 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | Positive findings indicate the implication of genetic polymorphisms of proinflammatory cytokines in premature birth; angiotensin converting enzyme in perinatal adaptation and angiotensin type 1 receptor in the closure of ductus arteriosus; surfactant proteins A and B in respiratory distress syndrome; interleukin (IL)-6 in sepsis, and IL-4-receptor alpha chain and IL-18 in NEC. | 16146753 | 2006 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | The ACE I/D polymorphism does not have a significant effect on the incidence or outcome of sepsis in ventilated VLBW infants. | 15549142 | 2005 |