We evaluated the expression of BTLA, CTLA-4, FCRL3, LAG-3, and TIGIT in tumor and non-tumor SS T-cells.Compared to CD4+ T helper cells from ten healthy individuals, tumor cells of eight SS patients had a significant upregulation of BTLA (1.5-fold; <i>p</i> < .0001), FRCL3 (2.2-fold; <i>p</i> < .0028) and TIGIT (2.2-fold; <i>p</i> < .0003) expression.