We explore RBC storage stability and post-transfusion recovery in murine models of allogeneic and xenogeneic transfusion using blood from humanized transgenic sickle cell hemizygous mice (Hba<sup>tm1Paz</sup>Hbb<sup>tm1Tow</sup>Tg(HBA-HBBs)41Paz/J) and human donors with a common genetic mutation sickle cell trait (HbAS).