| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.060 | AlteredExpression | group | BEFREE | Psoriasin is a noticeably over-expressed protein found in the skin lesions of psoriatic patients. | 31745628 | 2020 | ||||
|
0.060 | Biomarker | group | BEFREE | Psoriasin (S100A7) is an 11-kDa small calcium binding protein initially isolated from psoriatic skin lesions. | 28393239 | 2017 | ||||
|
0.060 | Biomarker | group | BEFREE | In contrast, other antimicrobial peptides expressed in psoriatic skin including elafin, hBD1, and psoriasin (S100A7) did not show similar activities. hBD2, hBD3, and lysozyme were detected in psoriatic skin lesions in the vicinity of pDCs and found to cooperate with LL37 to induce high levels of IFN production by pDCs, suggesting their concerted role in the pathogenesis of psoriasis. | 25332209 | 2015 | ||||
|
0.060 | AlteredExpression | group | BEFREE | S100A7 is a small calcium binding protein, which has been shown to be differentially expressed in psoriatic skin lesions, as well as in squamous cell tumors of the skin, lung and breast. | 18320059 | 2008 | ||||
|
0.060 | Biomarker | group | BEFREE | The overexpression of MLH-1, which codes for a DNA mismatch repair protein, and psoriasin, which codes for a specific chemoattractant factor for CD4+ T cells, implicated in the pathogenesis of inflammatory skin disease, and expressed in excess during abnormal pathways of cell growth, may shed light on the pathogenesis of the proliferative skin lesion. | 16965334 | 2006 | ||||
|
0.060 | AlteredExpression | group | BEFREE | All of these conditions are characteristic of high-grade DCIS and psoriatic skin lesions; therefore, the same mechanisms may be responsible for increased expression of psoriasin in vitro and in vivo. | 11782356 | 2002 |