Gene: CLOCK ×
Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 9575
Gene Symbol: CLOCK
CLOCK 		0.060 Biomarker phenotype BEFREE The role of clock genes in ADHD patients with comorbid aggression awaits further research; therefore we also indicate directions for future studies to help increase understanding of the underlying mechanisms in ADHD with comorbid aggression and sleep disturbances. 27836462 2018
Entrez Id: 9575
Gene Symbol: CLOCK
CLOCK 		0.060 GeneticVariation phenotype BEFREE Physiology and behaviour are critically dependent on circadian regulation via a core set of clock genes, dysregulation of which leads to metabolic and sleep disturbances. 29982483 2018
Entrez Id: 9575
Gene Symbol: CLOCK
CLOCK 		0.060 GeneticVariation phenotype BEFREE The main positive findings refer to associations between selected polymorphisms and: 1) chronotype with the ARNTL gene (rs11824092 and rs1481892) and the CLOCK (rs1268271) 2) sleep duration with the CLOCK gene (rs3805148) and the TIM gene (rs2291739) 3) daytime dysfunction with the PER3 gene (rs228727, rs228642, rs10864315) 4) subjective sleep quality with the ARNTL gene (rs11824092, rs1982350) 5) sleep disturbances with the ARNTL gene (rs11600996) We also found the significant epistatic interactions between polymorphism of the PER3 gene (rs2640909) & the CLOCK gene (rs11932595) and following sleep quality variables: sleep duration, habitual sleep efficiency and subjective sleep quality. 27102916 2016
Entrez Id: 9575
Gene Symbol: CLOCK
CLOCK 		0.060 Biomarker phenotype BEFREE Sleep disturbances and circadian CLOCK genes in borderline personality disorder. 22806005 2012
Entrez Id: 9575
Gene Symbol: CLOCK
CLOCK 		0.060 GeneticVariation phenotype BEFREE 3111T/C clock gene polymorphism is not associated with sleep disturbances in untreated depressed patients. 20370469 2010
Entrez Id: 9575
Gene Symbol: CLOCK
CLOCK 		0.060 GeneticVariation phenotype BEFREE Sleep disturbances in major depressive disorder (MDD) are characterized by increased sleep latency, poorer sleep efficiency reduced latency to the first rapid eye movement (REM) sleep episode, and early-morning awakening, but there is little data to indicate a role of circadian clock genes in MDD. 17969870 2007