Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.560 Biomarker disease BEFREE In conclusion, PT increases hippocampal neurogenesis through increasing BDNF levels by some pathways other than demethylating BDNF CpGs and causes post SE newly-born neurons to integrate into normal circuits thus resulting in decreased spontaneous recurrent seizures and enhanced spatial memory. 31560103 2019
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.560 AlteredExpression disease BEFREE SE-induced activation of the BDNF receptor tyrosine kinase, TrkB, is one signaling pathway by which SE induces TLE. 30926745 2019
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.560 Biomarker disease BEFREE Available data support a direct implication of FGF-2 and BDNF in SE and in its consequences. 30159899 2018
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.560 Biomarker disease BEFREE Silencing Status Epilepticus-Induced BDNF Expression with Herpes Simplex Virus Type-1 Based Amplicon Vectors. 26954758 2016
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.560 Biomarker disease RGD On the other hand, if seizures were induced at the time endogenous BDNF was increased, SE-induced neuronal damage was exacerbated. 19686240 2009
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.560 Biomarker disease RGD Localized delivery of fibroblast growth factor-2 and brain-derived neurotrophic factor reduces spontaneous seizures in an epilepsy model. 19366663 2009
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.560 Biomarker disease BEFREE Conversely, the infusion of recombinant human BDNF protein after SE greatly increased neuronal degeneration. 19686240 2009
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.560 Biomarker disease BEFREE Several studies suggest that brain-derived neurotrophic factor (BDNF) can exacerbate seizure development during status epilepticus (S.E.) and subsequent epileptogenesis in the adult brain. 14643774 2003
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.560 Biomarker disease CTD_human These results provide a complete description of changes in mRNA levels of neurotrophins and their receptors in the forebrain after SE and supply additional data supporting the view that neurotrophin gene expression is related to abnormal neuronal activity. 8635431 1996
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.560 Biomarker disease CTD_human The regulation of BDNF, trkB, and NGF mRNA was studied by in situ hybridization at 1, 3, 6, and 24 h after induction of limbic motor status epilepticus. 8821376 1996