Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
0.700 GeneticVariation group BEFREE Also, eIF2α-P stimulation by the phosphatase inhibitor SAL003 substantially increases Trastuzumab potency in resistant HER2+ breast and gastric tumors. 31086176 2019
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
0.700 Biomarker group BEFREE Antibody-drug conjugates with HER2-targeting antibodies from synthetic antibody libraries are highly potent against HER2-positive human gastric tumor in xenograft models. 30365359 2019
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
0.700 Biomarker group BEFREE However, the cellular distribution of HER2 protein in gastric tumors is dynamic, and HER2 internalization decreases antibody binding to tumor cells. 31171598 2019
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
0.700 Biomarker group BEFREE Thus, this study evaluated the tumor regression grading (TRG) in a series of post-treatment gastric tumors and its associations with HER2, MET, and FOXP3 expression. 29696715 2018
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
0.700 Biomarker group BEFREE HER2-positivity was significantly higher in males (16.1% vs. 9.6% in females), in gastroesophageal versus stomach tumors (22.1% vs. 12.9%), in biopsy versus surgical samples (18.3% vs. 13.0%), in intestinal tumor subtypes versus diffuse (21.5% vs. 4.8%) and mixed types (21.5% vs. 8.5%) (P<0.001), in mixed versus diffuse types (8.5% vs. 4.8%), and in "other" versus diffuse types (11.7% vs. 4.8%; P=0.002). 27490762 2018
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
0.700 AlteredExpression group BEFREE This study demonstrated a significant difference in the overexpression of HER2/neu in gastric tumors. 25292034 2014
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
0.700 AlteredExpression group BEFREE HER2/neu overexpression (IHC 3+) was detected in 19% (10 of 54) of gastric tumors, and overall correlation between manual HER2/neu IHC interpretation and IA interpretation was 78% (42 of 54). 22646266 2012
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
0.700 Biomarker group CTD_human MET amplification identifies a small and aggressive subgroup of esophagogastric adenocarcinoma with evidence of responsiveness to crizotinib. 22042947 2011
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
0.700 Biomarker group CTD_human Clinicopathologic characteristics of patients with stage III/IV (M(0)) advanced gastric cancer, according to HER2 status assessed by immunohistochemistry and fluorescence in situ hybridization. 21532492 2011
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
0.700 Biomarker group BEFREE Despite advances with traditional single genes molecular research, including rare mutations in BRCA1/2 and CDH1 for primary prevention and trastuzumab for treating HER2-overexpressing breast and gastric tumors, overall, treatment failure and death rates are still alarmingly high. 20975737 2011
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
0.700 Biomarker group LHGDN Association of ERBB2 gene status with histopathological parameters and disease-specific survival in gastric carcinoma patients. 19156142 2009
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
0.700 AlteredExpression group LHGDN Impact of insulin-like growth factor type 1 receptor, epidermal growth factor receptor, and HER2 expressions on outcomes of patients with gastric cancer. 18483367 2008
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
0.700 Biomarker group LHGDN HER-2/neu amplification is an independent prognostic factor in gastric cancer. 16868827 2006
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
0.700 AlteredExpression group LHGDN Role of receptor tyrosine kinases in gastric cancer: new targets for a selective therapy. 16733844 2006
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
0.700 Biomarker group LHGDN Potential prognostic significance of p185(HER2) overexpression with loss of PTEN expression in gastric carcinomas. 16457151 2006
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
0.700 AlteredExpression group LHGDN Membranous levels of c-erbB-2 oncoprotein in gastric cancer: their relationship with clinicopathological parameters and their prognostic significance. 15646832 2005
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
0.700 AlteredExpression group LHGDN Coamplified and overexpressed genes at ERBB2 locus in gastric cancer. 14991576 2004
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
0.700 Biomarker group CTD_human Prognostic implications of the expression of erbB2, topoisomerase II alpha and thymidylate synthase in metastatic gastric cancer after fluorouracil-based therapy. 15640503 2004
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
0.700 GeneticVariation group LHGDN A single nucleotide polymorphism in the transmembrane domain coding region of HER-2 is associated with development and malignant phenotype of gastric cancer. 14520697 2003
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
0.700 AlteredExpression group BEFREE Thus, overexpression of normal size erbB-2 mRNA accompanies gene amplification in primary stomach tumors. 2573419 1989
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
0.700 CausalMutation group CGI
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
0.700 GenomicAlterations group CGI
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
0.700 CausalMutation group CLINVAR
Entrez Id: 324
Gene Symbol: APC
APC
0.640 GeneticVariation group BEFREE Endoscopic findings of GN and background mucosa, and histopathological findings, including phenotypic expression of GN and mutation locus of adenomatous polyposis coli (APC) gene, were evaluated. 31411765 2019
Entrez Id: 324
Gene Symbol: APC
APC
0.640 Biomarker group BEFREE The truncated APC gene retained 3 repeats in 88% (7/8) of FAP duodenal tumors, 100% (26/26) of gastric tumors retained 2 or 3 repeats and 83% (5/6) of desmoid tumors retained 2 repeats. 18224684 2008