Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.600 Biomarker disease BEFREE Artesunate markedly ameliorated aspirin induced gastric injury in rats by targeting oxidative stress and COX-2 dependent as well as COX-2 independent proinflammatory signaling pathways and could have a therapeutic potential in gastric ulcer disease. 29397336 2018
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.600 Biomarker disease BEFREE Taken together, the activation of AMPK by rebamipide may be a molecular mechanism that contributes to induction of COX-2, probably resulting in protection against gastric ulcers. 28011266 2017
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.600 AlteredExpression disease BEFREE Implication of gastrin in cyclooxygenase-2 expression in Helicobacter pylori infected gastric ulceration. 11519793 2001
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.600 Biomarker disease BEFREE Most were reported to be free of adverse gastrointestinal effects, but it should be noted that in the healing process of gastric ulcers and in sodium-restricted states, adverse effects of selective COX-2 inhibitors could be expected. 11028754 2000
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.600 Biomarker disease BEFREE Current study was designed to understand the gastric ulcer healing mechanism of rhamnogalacturonan-I type pectic polysaccharide of black cumin (BCPP) utilizing acetic acid induced gastric ulcers in rats.BCPP fed groups at 200mg/kg b.w. for 10days showed up to 85% healing of gastric ulcers with modulation of key molecular events involved in ulcer healing process such as increase in gastric mucin content, cyclooxygenase-2 (Cox-2) and prostaglandin E<sub>2</sub> (PGE<sub>2</sub>). 28322956 2017
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.600 AlteredExpression disease BEFREE We constructed a prospective cohort study to evaluate how these two factors influence the expression of COX-2 mRNA in gastric antral, corpus mucosa, and gastric ulcer. 15599211 2005
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.600 Biomarker disease BEFREE In the following article, the phenotypes of the two Ptgs (genes coding for COX-1 and COX-2) knockouts are summarized, and recent studies to investigate the effects of COX deficiency on cancer susceptibility, inflammatory response, gastric ulceration, and female reproductive processes are discussed. 10487525 1999
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.600 AlteredExpression disease BEFREE Both COX-1 and COX-2 are up-regulated in human gastric ulcers. 11136275 2001
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.600 Biomarker disease BEFREE Recent studies suggest that cyclooxygenase 2 (COX-2) inhibitors may enhance the toxic effects of anticancer drugs on tumor cells, including oral squamous cell carcinoma (OSCC), but its long-term use can cause side effects such as stomach ulcers and myocardial infarction. 28342204 2017
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.360 GeneticVariation disease BEFREE The G1612A(rs10434) and C936T(rs3025039) polymorphisms in the 3' untranslated region (3'-UTR) of VEGF gene were genotyped in a total of 844 subjects including 385 GC, 143 ulcer including 98 gastric ulcer (GU), 45 duodenal ulcer (DU), and 316 nonulcer subjects. 19496079 2009
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.360 Biomarker disease BEFREE These data suggest that VEGF may play a role in angiogenesis in the process of gastric ulcer healing. 9177300 1997
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.360 GeneticVariation disease BEFREE Thus, we investigated the influence of functional genetic variants in the IL-1 gene cluster on the development of gastric ulcer disease. 15885804 2005
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.360 GeneticVariation disease BEFREE Even though the case-control study between non-ulcer dyspepsia (NUD) and gastric ulcer (GU) patients was done in 10 SNP of the VEGF gene including -2488C/T, -634G/C, -7C/T, 3436G/C, 6112C/A, 6894C/T, 9374G/A, 9812C/T, 13128C/T, and 13553C/T, the analysis showed no statistically significant association between NUD and GU. 19120886 2008
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.360 AlteredExpression disease BEFREE Shh (r = 0.8, P < 0.001) and IL1β (r = 0.7, P < 0.005) expression was each positively correlated with the speed of gastric ulcer healing, but multivariate analysis showed that Shh expression was the only significant parameter (P = 0.045). 24224878 2014
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.360 AlteredExpression disease BEFREE The transient, local expression of VEGF in ulcerated tissue might be a new therapeutic strategy in the treatment of gastric ulcer disease. 15638736 2005
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.360 Biomarker disease BEFREE Oligonol decreased the reactive oxygen species levels and elevated levels of both inflammatory mediators and cytokines (p-IκB, NF-κBp65, COX-2, iNOS, TNF-α, and IL-1β) in the RE and GU models. 29243969 2017
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.360 Biomarker disease BEFREE Relation of hypoxia-inducible factor-1alpha to vascular endothelial growth factor and vasoactive factors during healing of gastric ulcers. 15838334 2004
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.360 GeneticVariation disease BEFREE Association of IL1B -511C/-31T haplotype and Helicobacter pylori vacA genotypes with gastric ulcer and chronic gastritis. 20979650 2010
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.360 Biomarker disease BEFREE The present study evaluates the effects of extract of Musa sapientum fruit (MSE) on ulcer index, blood glucose level and gastric mucosal cytokines, TNF-α and IL-1β and growth factor, TGF-α (affected in diabetes and chronic ulcer) in acetic acid (AA)-induced gastric ulcer (GU) in diabetic (DR) rat. 24192345 2013
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.350 GeneticVariation disease BEFREE Patients with gastric ulcer had a lower frequency of the TNF-308 allele 2 and a higher frequency of the LTANcoI 2.2 genotype when compared with duodenal ulcer patients (P < 0.01 and P = 0.03, respectively). 11781708 2001
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.350 Biomarker disease BEFREE The present study evaluates the effects of extract of Musa sapientum fruit (MSE) on ulcer index, blood glucose level and gastric mucosal cytokines, TNF-α and IL-1β and growth factor, TGF-α (affected in diabetes and chronic ulcer) in acetic acid (AA)-induced gastric ulcer (GU) in diabetic (DR) rat. 24192345 2013
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.350 Biomarker disease BEFREE To clarify the role of human gastric fibroblasts in acute inflammatory conditions such as gastric ulcer, the effects of interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha on the expression of uPA and uPAR, which were suggested to be associated with tissue remodeling, in gastric fibroblasts were investigated. 14714609 2003
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.350 GeneticVariation disease BEFREE Polymorphisms in TNF-alpha rather than IL-1beta are associated with increased risk for gastric ulcers and gastric cancer in Japan. 17201881 2007
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.350 Biomarker disease BEFREE Positive H. pylori status and host TNF-alpha promoter susceptibility could not explain the pathogenesis of higher GU prevalence and pathogenesis of AIP in our population. 19276869 2009
Entrez Id: 5742
Gene Symbol: PTGS1
PTGS1
0.340 AlteredExpression disease BEFREE Both COX-1 and COX-2 are up-regulated in human gastric ulcers. 11136275 2001