| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.070 | GeneticVariation | disease | BEFREE | Single nucleotide polymorphism (SNP) of the TNF-α promoter region can potentially affect the function or expression of this cytokine, and thus modulate the risk of occurrence and intensity of OM and shortening of overall survival (OS). | 31076897 | 2020 | ||||
|
0.070 | Biomarker | disease | BEFREE | Proinflammatory cytokines (including TNF-α) play a key role in the development of OM.Genetic alterations, i.e. single nucleotide polymorphisms (SNPs) within genes encoding for receptors for TNF (ie.TNFRSF1A) may change their function. | 28401452 | 2018 | ||||
|
0.070 | Biomarker | disease | BEFREE | Tumor necrosis factor (TNF) antagonists achieved complete response for pyoderma gangrenosum in 21%-25% of patients in interventional studies and in 92%-100% patients in non-interventional studies, with similar results for other cutaneous manifestations such as erythema nodosum or stomatitis. | 27392760 | 2017 | ||||
|
0.070 | AlteredExpression | disease | BEFREE | Patients with HSV infection, OC, and OM showed higher salivary TNF levels during follow-up (HR: 3.52, 95% CI: 1.35-9.14, p = 0.010). | 28403570 | 2017 | ||||
|
0.070 | AlteredExpression | disease | BEFREE | Compared with blank or vehicle-treated hamsters, the irradiated mucosa treated with phenylbutyrate had significantly lower oxidative stress and tumor necrosis factor-alpha expression and less severe oral mucositis of a shorter duration. | 19351790 | 2009 | ||||
|
0.070 | Biomarker | disease | BEFREE | A secondary purpose was to assess the effectiveness of molecular biology methods for measuring TNF-alpha concentrations in plasma, saliva, and buccal epithelial cells in patients with oral mucositis undergoing HSCT. | 18164921 | 2007 | ||||
|
0.070 | GeneticVariation | disease | BEFREE | Similarly, the frequency of the IL-1beta-511 TC and TT genotypes and the frequency of the TNF-alpha-1031 TT genotype were significantly higher in patients with grades 1-4 thrombocytopenia (P=0.015; Cr-OR=2.9) and stomatitis (P=0.02; Cr-OR=3.1), respectively. | 16820919 | 2006 |