|
ADCYAP1R1
|
0.100 |
Biomarker
|
disease |
BEFREE |
Moreover, a neurobiological substrate that may account for the observed link between PAC1R and PTSD in women, but not men, has yet to be identified.
|
29353055 |
2018 |
|
ADCYAP1R1
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results provide evidence for an association between ADCYAP1R1 and PTSD and indicate that there may indeed be sex differences.
|
28746747 |
2017 |
|
ADCYAP1R1
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Pituitary adenylate cyclase-activating polypeptide (PACAP; Adcyap1) and its cognate PAC1 receptor (Adcyap1r1) are expressed in peripheral nociceptive pathways, participate in anxiety-related responses and have been have been linked to posttraumatic stress disorder and other mental health afflictions.
|
28057459 |
2017 |
|
ADCYAP1R1
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In women with low serum E2, the CC genotype associates with lower ADCYAP1R1 expression, which further associates with higher PTSD symptoms.
|
27959335 |
2016 |
|
ADCYAP1R1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Notably, in heavily traumatized human subjects, there appears to be a robust sex-specific association of PACAP blood levels and PAC1R gene variants with fear physiology, PTSD diagnosis, and symptoms, specifically in females.
|
28179812 |
2016 |
|
ADCYAP1R1
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results suggest that impaired contextual conditioning in the hippocampal formation may mediate the association between PAC1-R and PTSD symptoms.
|
25680674 |
2015 |
|
ADCYAP1R1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Individual differences in ADCYAP1R1 genotype may contribute to dysregulated fear circuitry known to play a central role in PTSD and other anxiety disorders.
|
24516127 |
2014 |
|
ADCYAP1R1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
No significant main effects were observed for ADCYAP1R1 genotype on either PTSD/PTS severity.
|
23280952 |
2013 |
|
ADCYAP1R1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
(2011); Nature 470:492-497] demonstrated that a variant, rs2267735, in the gene encoding PAC1 (ADCYAP1R1) is associated with post-traumatic stress disorder (PTSD) in a primarily African-American cohort of highly traumatized females.
|
23505260 |
2013 |
|
ADCYAP1R1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The present study investigated the association between ADCYAP1R1 rs2267735 genotype and PTSD symptoms in a highly traumatized sample of Chinese adults.
|
23394710 |
2013 |
|
ADCYAP1R1
|
0.100 |
Biomarker
|
disease |
BEFREE |
These data suggest that perturbations in the PACAP-PAC1 pathway are involved in abnormal stress responses underlying PTSD.
|
21350482 |
2011 |