Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2153
Gene Symbol: F5
F5
0.500 GeneticVariation group GWASCAT Genome-wide association analysis of self-reported events in 6135 individuals and 252 827 controls identifies 8 loci associated with thrombosis. 26908601 2016
Entrez Id: 2153
Gene Symbol: F5
F5
0.500 Biomarker group BEFREE Studies from the different ethnic regions of world have reported variable results on association of Apolioprotein E (APOE), Methylenetetrahydrofolate reductase (MTHFR), Endothelial Nitric Oxide Synthase (ENOS), Factor V Leiden (F5), Cytochrome P450 4F2 (CYP4F2), beta-fibrinogen and Phosphodiesterase 4D (PDE4D) gene in stroke. 24090469 2013
Entrez Id: 2153
Gene Symbol: F5
F5
0.500 GeneticVariation group BEFREE Prothrombin G20210A and factor V Leiden polymorphisms in stroke. 21701789 2012
Entrez Id: 2153
Gene Symbol: F5
F5
0.500 GeneticVariation group BEFREE He had stroke as part of a generalized bleeding-thromboembolic incident caused by combined heterozygote mutation of factor V(Leiden) and prothrombin G20210A, each of which was then found in a heterozygote form in each of the 2 parents. 22948176 2012
Entrez Id: 2153
Gene Symbol: F5
F5
0.500 GeneticVariation group BEFREE Data of literature are not clear about what kind of genetic polymorphism is prominent in the genesis of cerebral stroke (factor V leiden, MTHFR, activated protein C resistance, factor II G20210A). 21113717 2011
Entrez Id: 2153
Gene Symbol: F5
F5
0.500 Biomarker group BEFREE A 45-year-old man with heterozygous Factor V Leiden presented with his third cerebrovascular accident despite being on warfarin at a therapeutic international normalized ratio. 21605293 2011
Entrez Id: 2153
Gene Symbol: F5
F5
0.500 GeneticVariation group BEFREE Molecular characterization of factor V leiden G1691A and prothrombin G20210A mutations in Saudi newborns with stroke. 21461667 2011
Entrez Id: 2153
Gene Symbol: F5
F5
0.500 Biomarker group BEFREE The magnitudes of stroke risk observed for factor V Leiden, ACE, MTHFR and prothrombin, but not PAI-1, polymorphisms, are consistent with risks associated with equivalent changes in activated protein C resistance, ACE activity, homocysteine, prothrombin, and PAI-1 levels, respectively. 20161734 2010
Entrez Id: 2153
Gene Symbol: F5
F5
0.500 Biomarker group BEFREE Among the 9 "selected" ischemic stroke studies, factor V Leiden was more strongly associated with stroke (OR, 2.73; 95% CI, 1.98-3.75), whereas among the 8 "unselected" ischemic stroke studies, the association between factor V Leiden and stroke was substantially weaker (OR, 1.40; 95% CI, 0.998-1.95). 20616326 2010
Entrez Id: 2153
Gene Symbol: F5
F5
0.500 GeneticVariation group BEFREE MTHFR 677TT (P < .001) and 1298CC (P < .001), but not factor V-Leiden (P = .179), genotypes were associated with stroke. 19717029 2009
Entrez Id: 2153
Gene Symbol: F5
F5
0.500 Biomarker group BEFREE Activated protein C resistance has a stronger association with stroke than factor V Leiden and may be caused by other factors such as elevated factor VIII levels in the Asian Indian population apart from factor V Leiden itself. 19560187 2009
Entrez Id: 2153
Gene Symbol: F5
F5
0.500 GeneticVariation group BEFREE Ninety-nine patients were tested for the presence of common polymorphisms related to thrombophilia (prothrombin and factor V Leiden) in order to assess genetic risk factors, and several parameters classically associated with vascular disorders (cardiovascular events, brain stroke and antiphospholipid syndrome) were evaluated. 19005247 2009
Entrez Id: 2153
Gene Symbol: F5
F5
0.500 Biomarker group BEFREE Factor V Leiden and the risk of venous thrombosis, myocardial infarction, and stroke: a case-control study in Venezuela. 19604111 2009
Entrez Id: 2153
Gene Symbol: F5
F5
0.500 GeneticVariation group LHGDN Stroke severity, long-term recovery, and recurrence rates seemed similar irrespective of FVL status. 19132201 2009
Entrez Id: 2153
Gene Symbol: F5
F5
0.500 Biomarker group LHGDN Factor v Leiden and antiphospholipid antibodies in either mothers or infants increase the risk for perinatal arterial ischemic stroke. 18927445 2009
Entrez Id: 2153
Gene Symbol: F5
F5
0.500 GeneticVariation group LHGDN The coagulation factor V Leiden, MTHFRC677T variant and eNOS 4ab polymorphism in young Chinese population with ischemic stroke. 18602910 2008
Entrez Id: 2153
Gene Symbol: F5
F5
0.500 GeneticVariation group LHGDN Lower contribution of factor V Leiden or G202104 mutations to ischemic stroke in patients with clinical risk factors: pair-matched case-control study. 17456629 2007
Entrez Id: 2153
Gene Symbol: F5
F5
0.500 GeneticVariation group LHGDN Matched case-control study on factor V Leiden and the prothrombin G20210A mutation in patients with ischemic stroke/transient ischemic attack up to the age of 60 years. 15947254 2005
Entrez Id: 2153
Gene Symbol: F5
F5
0.500 GeneticVariation group LHGDN The prevalence of FVL mutation was higher among pediatric stroke patients than among control subjects (p < 0.05). 15678277 2005
Entrez Id: 2153
Gene Symbol: F5
F5
0.500 Biomarker group BEFREE The likely candidate genes associated with stroke are those that are associated with matrix deposition (stromelysin-1, MMP3), inflammation (IL-6), and lipid metabolism (hepatic lipase, APOE, PON1) and clotting (factor V Leiden, fibrinogen). 15767859 2005
Entrez Id: 2153
Gene Symbol: F5
F5
0.500 GeneticVariation group LHGDN Homozygosity for factor V Leiden mutation and ischemic stroke: two case-reports and review of the literature. 15592740 2004
Entrez Id: 2153
Gene Symbol: F5
F5
0.500 Biomarker group CTD_human Meta-analysis of genetic studies in ischemic stroke: thirty-two genes involving approximately 18,000 cases and 58,000 controls. 15534175 2004
Entrez Id: 2153
Gene Symbol: F5
F5
0.500 GeneticVariation group LHGDN Odd ratio (OR) for cryptogenic stroke was 2.62 (95% CI, 0.49-13.95) for FVL and 3.75 (95% CI, 1.05-13.34) for PT 20210 and 3.28 (95% CI, 1,17-9.20) for some recognized genetic thrombophilic defect. 15116266 2004
Entrez Id: 2153
Gene Symbol: F5
F5
0.500 GeneticVariation group BEFREE The association between factor V Leiden (FVL) and prothrombin G20210A (PT 20210) mutations and ischemic stroke remains controversial, particularly in young adults with cryptogenic stroke. 15116266 2004
Entrez Id: 2153
Gene Symbol: F5
F5
0.500 Biomarker group LHGDN However, given the suggestive nature of our findings, further study in even larger numbers of patients is needed to clarify the impact of factor V Leiden on stroke risk in atrial fibrillation. 14574075 2003