Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.400 AlteredExpression group BEFREE Injection of lentiviral miR-126-5p improved behavioral outcomes at 3 days after stroke (<i>P</i><0.05). miR-126-3p and -5p overexpression downregulated the expression of proinflammatory cytokines IL-1β and TNF-α and adhesion molecules VCAM-1 and E-selectin, as well as decreased MPO<sup>+</sup> (myeloperoxidase positive) cell numbers at 3 days after ischemia (<i>P</i><0.05). 31822249 2020
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.400 Biomarker group BEFREE Interleukin-1β is a potent proinflammatory cytokine that plays a key role in the pathogenesis of the brain aging and diverse range of neurological diseases including Alzheimer's disease, Parkinson's disease, stroke and persistent pain. 31535638 2020
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.400 Biomarker group BEFREE While the role of IL-1β (main released isoform) has been well studied in stroke, the role of the IL-1α isoform remains largely unknown. 31727174 2019
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.400 AlteredExpression group BEFREE In both a murine model of stroke and in patients, increased IL-1β levels were observed after stroke, and hypothermia treatment was associated with lower IL-1β levels. 31644666 2019
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.400 Biomarker group BEFREE Interleukin(IL)-37 is an immunosuppressive cytokine belonging to the IL-1 superfamily with no mouse homologue yet identified, the effects of which have not been studied in stroke. 31061403 2019
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.400 GeneticVariation group BEFREE The objective of the study is to assess the modulatory effect of IL-1 genotypes on risk mediated by Lp(a) METHODS: We assessed whether IL-1 genotypes modulate the effect of Lp(a) on major adverse cardiovascular events (cardiovascular death, myocardial infarction, and stroke/transient ischemic attack) and angiographically determined coronary artery disease (CAD). 29310992 2019
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.400 Biomarker group BEFREE After adjusting for stroke severity and infections, higher ex vivo TNFα (OR 0.29, 95%CI 0.11-0.72, P = 0.01), IP-10 (OR 0.25, 95%CI 0.08-0.73, P = 0.01), IL-1β (OR 0.42, 95%CI 0.20-0.89, P = 0.02), and IL-12 (OR 0.07, 95%CI 0.01-0.70, P = 0.02) release was associated with the reduced risk of delirium. 29669581 2018
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.400 Biomarker group BEFREE These data provide evidence that serum TNF-α and IL-1β concentrations are related to poor long-term outcomes after stroke in the presence of particular alleles. 29161722 2018
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.400 AlteredExpression group BEFREE Intracellular levels of TNF-α and IL-1β in microglia peaked at 3 days of stroke, and IL-4<sup>+</sup> IL-10<sup>+</sup> double-positive microglia significantly increased at day 10. 29131464 2018
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.400 Biomarker group BEFREE This work was designed to examine the effect of mouse recombinant resistin on mRNA expression of Tumor necrosis factor-α (TNF-α), Interleukin-1β (IL-1β), Interleukin-10 (IL-10), Transforming growth factor-β1 (TGF- β1), and Heat shock protein-70 (HSP-70) in mouse model of stroke. 30120034 2018
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.400 Biomarker group BEFREE Given the established role of IL-1β in stroke, we tested the efficacy of the murine Canakinumab-equivalent antibody in a mouse model of ischaemic stroke. 29788103 2018
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.400 Biomarker group BEFREE Stroke significantly increases macrophage infiltration into the heart and increases IL-1β, IL-6, MCP-1, TGF-β and macrophage-associated inflammatory cytokine levels in the heart as well as induces cardiac-fibrosis and hypertrophy. 30465612 2018
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.400 AlteredExpression group BEFREE Stroke and co-morbidities are associated with raised levels of the pro-inflammatory cytokine interleukin-1 (IL-1). 27856349 2017
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.400 AlteredExpression group BEFREE Quantitative PCR analysis of whole cell lysate as well as flow-sorted myeloid cells from the perilesional cortex showed increased cellular interleukin 1 beta (IL-1β), interleukin 6 (IL-6), and tumor necrosis factor alpha (TNF-α) mRNA levels but reduced plasma levels of these cytokines in MS P2X4R KO mice after stroke. 28751018 2017
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.400 AlteredExpression group BEFREE These findings indicate the important roles that TNF-α and IL-1β serum levels play regarding the risk of PSD, particularly during the acute phase of stroke and in patients with genetic susceptibility. 28844626 2017
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.400 Biomarker group BEFREE MAPC treatment restored spleen mass reduction caused by stroke, elevated Treg cells within the spleen, increased IL-10 and decreased IL-1β released by splenocytes. 28263009 2017
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.400 GeneticVariation group BEFREE However, no associations of IL-1β-511C/T and IL-RN polymorphisms on stroke risk in overall analysis or subgroup analysis. 25917615 2015
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.400 AlteredExpression group BEFREE Increased expression of SFSR3 may decrease IL-1β expression and secretion, resulting in reduced risk of atherosclerosis and stroke. 24190014 2014
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.400 GeneticVariation group BEFREE Subjects carrying the TT genotype of the -511C/T IL-1beta polymorphism showed a decreased risk of MI (odds ratio [OR], 0.36; 95% CI, 0.20 to 0.64) and stroke (OR, 0.32; 95% CI, 0.13 to 0.81) after adjustment for conventional risk factors. 15539626 2005
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.400 GeneticVariation group LHGDN Interleukin 1 beta polymorphism (-511) and risk of stroke due to small vessel disease. 16131798 2005
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.400 GeneticVariation group LHGDN Subjects carrying the TT genotype of the -511C/T IL-1beta polymorphism showed a decreased risk of MI (odds ratio [OR], 0.36; 95% CI, 0.20 to 0.64) and stroke (OR, 0.32; 95% CI, 0.13 to 0.81) after adjustment for conventional risk factors. 15539626 2005
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.400 GeneticVariation group BEFREE Interleukin 1 beta polymorphism (-511) and risk of stroke due to small vessel disease. 16131798 2005
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.400 Biomarker group CTD_human The novel beta-blocker, carvedilol, provides neuroprotection in transient focal stroke. 10950380 2000
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.400 Biomarker group BEFREE IL-1 mediates host defence responses to local and systemic disease and injury (e.g. fever, slow-wave sleep, appetite suppression and neuroendocrine responses) and to neuroinflammation and cell death in neurodegenerative conditions, such as stroke and head injury. 11137152 2000