Exosomes from miRNA-126-modified ADSCs promotes functional recovery after stroke in rats by improving neurogenesis and suppressing microglia activation.
<b>Results:</b> The miR-126 gene rs4636297 polymorphism was associated with decreased small vessel stroke risk (GA vs. GG: odds ratio (OR) = 0.62, <i>p</i> = .015; GA + AA vs. GG: OR = 0.637, <i>p</i> = .018; A vs. G: OR = 0.696, <i>p</i> = .033).
MiR-126<sup>-/-</sup> EC-Exo treatment significantly decreases miR-126 expression in serum and brain, as well as attentuates EC-Exo treatment-induced functional improvement and does not significantly increase axon and myelin density, vascular density, arterial diameter or induce M2 macrophage polarization in T2DM-stroke mice.