Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
0.390 GeneticVariation group BEFREE Childhood adversities and the 5-HTTLPR polymorphism are involved in the aetiology of substance use disorders though findings exploring the existence of a gene-environment interaction were inconclusive. 31488488 2019
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
0.390 GeneticVariation group BEFREE This is the first study to show that both familial risk of SUD and 5-HTTLPR variation impact performance on the IGT. 24988263 2014
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
0.390 GeneticVariation group BEFREE Using the genotype data of 55 studies (7999 cases, 8264 controls, and 676 families or parent-offspring trios) published in the past 15 years, we have conducted comprehensive meta-analyses to examine the associations of the 5-HTTLPR and STin2 polymorphisms with substance use disorder. 23518607 2013
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
0.390 GeneticVariation group BEFREE SUD and NSUD disorders were diagnosed according to the fourth edition of the Diagnostic and Statistical Manual of Mental Health Disorders criteria using the Psychiatric Research Interview for Substance and Mental Disorders.Incidence Rates (IR) are presented.The 5-HTTLPR polymorphism was analyzed.Hardy-Weinberg equilibrium was studied. 19878141 2010
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
0.390 Biomarker group BEFREE We found three candidate genes associated with both BD and TUD (COMT, SLC6A3, and SLC6A4) and commonality analysis suggests that these genes interact in predisposing psychiatric and substance use disorders. 20102619 2010
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
0.390 GeneticVariation group BEFREE A total of 110 adult patients with ASD (n=61) or ADHD (n=49) with or without a lifetime history of SUD participated in a study in which we genotyped polymorphisms in five known candidate genes for (one of) the disorders, i.e. the 5HTTLPR in SLC6A4/5-HTT, rs1800497 (TaqIA C>T) in DRD2, rs7794745 in CNTNAP2, rs1843809 in TPH2, and rs6565113 in CDH13. 20446882 2010
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
0.390 Biomarker group CTD_human Serotonin transporter promoter region polymorphisms do not influence treatment response to escitalopram in patients with major depression. 19272758 2009
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
0.390 GeneticVariation group BEFREE On the whole, our preliminary data suggest that the association between 5-HT transporter polymorphism and psycho-stimulant use may be mediated by mother-child relationship and parental attachment perception, both being environmental and genetic factors involved in the proneness to substance use disorders, particularly in aggressive-antisocial individuals. 16972224 2007
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
0.390 GeneticVariation group BEFREE Serotonin transporter promoter polymorphism (5-HTTLPR) genotype was previously found associated with substance use disorders, particularly in the subjects with comorbid antisocial behavior, and with temperament and personality traits at risk for substance abuse. 15666036 2005
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
0.390 GeneticVariation group BEFREE Our data suggest that a decreased expression of the gene encoding the 5-HTT transporter, due to "S" promoter polymorphism, may be associated with an increased risk for substance use disorders, particularly in the subjects with more consistent aggressiveness and impulsiveness. 15048645 2004