However, neutrophil uptake of MRSA and <i>S. pneumoniae</i> was significantly reduced upon IFN-λ treatment during influenza superinfection <i>in vivo</i> Together, these data support the theory that IFN-λ decreases neutrophil motility and function in the influenza-infected lung, which increases the bacterial burden during superinfection.
Similarly, in transient-transfection assays, both SV2-IFN and IE94-IFN gave only low basal mRNA synthesis, but superinfection with HSV again led to high-level accumulation of IFN mRNA.