Gene: SLPI ×
Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6590
Gene Symbol: SLPI
SLPI 		0.100 Biomarker disease BEFREE Arteriovenous malformations in hereditary haemorrhagic telangiectasia: looking beyond ALK1-NOTCH interactions. 26645978 2016
Entrez Id: 6590
Gene Symbol: SLPI
SLPI 		0.100 Biomarker disease BEFREE Endoglin and alk1 as therapeutic targets for hereditary hemorrhagic telangiectasia. 28796572 2017
Entrez Id: 6590
Gene Symbol: SLPI
SLPI 		0.100 GeneticVariation disease BEFREE Finally, tacrolimus stimulated Smad1/5/8 signaling in C2C12 cells expressing BMP9-unresponsive ALK1 HHT mutants and in HHT patient blood outgrowth ECs. 28973643 2017
Entrez Id: 6590
Gene Symbol: SLPI
SLPI 		0.100 Biomarker disease BEFREE Overall, our results indicate that the BMP9/ALK1 hub critically mediates vascular quiescence by limiting PI3K signaling and suggest that PI3K inhibitors could be used as novel therapeutic agents to treat hereditary hemorrhagic telangiectasia. 29449337 2018