|
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
GCA was mostly associated with class II genes (HLA-DRB1/HLA-DQA1) whereas TAK was mostly associated with class I genes (HLA-B/MICA).
|
28277489 |
2017 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
GCA incidence (n = 17 countries) was associated with population HLA-DRB1*04 allele frequency (P = 0.008; adjusted R(2) = 0.51 on univariable analysis, adjusted R(2) = 0.62 after also including latitude); latitude also made an independent contribution.
|
26223536 |
2015 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A multivariate model including class II amino acids of HLA-DRβ1 and HLA-DQα1 and one class I amino acid of HLA-B explained most of the HLA association with GCA, consistent with previously reported associations of classical HLA alleles like HLA-DRB1(∗)04.
|
25817017 |
2015 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The risk of GCA in HLA-DRB1*04 positive individuals homozygous for the FCGR2A-131R allele is increased almost six-fold compared with those with other FCGR2A genotypes who are HLA-DRB1*04 negative.
|
16846526 |
2006 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
[Extent and location of lesions in aorta and its main branches in patients with nonspecific aortoarteritis with various genotypes in the region of major histocompatibility complex].
|
16007032 |
2005 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
Our results suggest an association with IL-4 gene polymorphism that is dependent on HLA-DRB1 genotype in GCA susceptible individuals.
|
15570643 |
2004 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
DRB1*04 (OR, 1.9 [0.96 to 3.8]; P =.06), especially *0401 (OR, 2.8 [1 to 7.7]; P =.04), and DRB1*07 (OR, 2.3 [1.2 to 4.6]; P =.01) were more frequent in GCA than in PMR.
|
15305244 |
2004 |
|
HLA-DRB1
|
0.100 |
Biomarker
|
disease |
BEFREE |
DRB1*04 (OR, 1.9 [0.96 to 3.8]; P =.06), especially *0401 (OR, 2.8 [1 to 7.7]; P =.04), and DRB1*07 (OR, 2.3 [1.2 to 4.6]; P =.01) were more frequent in GCA than in PMR.
|
15305244 |
2004 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Conflicting HLA-DRB1 genotype results have been reported, and recent studies have shown that PMR and GCA have different expression of RANTES, TNFalpha microsatellite, and IL-6 promoter genetic polymorphisms.
|
15079760 |
2004 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest an association with IL-4 gene polymorphism that is dependent on HLA-DRB1 genotype in GCA susceptible individuals.
|
15570643 |
2004 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Patients with GCA in the first family shared the whole HLA genotype (A*24,*26, B*38,*55, DRB1*11,*14, DQB1*05,*07, DRB3*).
|
12136919 |
2002 |
|
HLA-DRB1
|
0.100 |
Biomarker
|
disease |
BEFREE |
HLA-DRB1*04 was found in 47% of patients with PMR only and in 54% of patients with GCA, which differed significantly from the 35% found in controls (p = 0.01).
|
12375325 |
2002 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
DRB1 alleles in polymyalgia rheumatica and rheumatoid arthritis in southern France.
|
11251689 |
2001 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Most studies have shown an association of GCA with HLA-DRB1 *04 alleles.
|
11299056 |
2001 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Visual complications in GCA were primarily associated with carriage of an HLA-DRB1*04 allele.
|
11469468 |
2001 |
|
HLA-DRB1
|
0.100 |
Biomarker
|
disease |
BEFREE |
In our patient population, GCA was associated with an increased frequency of HLA-DRB1*04 compared with PMR patients.
|
11407077 |
2001 |
|
HLA-DRB1
|
0.100 |
Biomarker
|
disease |
BEFREE |
In patients with isolated GCA, the primary association was with TNFa2, which was independent of the GCA associations with HLA-DRB1*0401 and *0101.
|
10943865 |
2000 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
HLA-DRB1, DQA1, and DQB1 alleles associated with giant cell arteritis in northern Italy.
|
10555899 |
1999 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
HLA-DRB1 alleles associated with polymyalgia rheumatica in northern Italy: correlation with disease severity.
|
10225816 |
1999 |
|
HLA-DRB1
|
0.100 |
Biomarker
|
disease |
BEFREE |
The distribution of DRB1*04 subtypes was similar in PMR and GCA, but different from RA and controls.
|
9458210 |
1998 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
GCA seems to be associated with HLA DRB1*04 (regardless of the subtype) and this association appears to be accompanied by corticosteroid resistance, suggesting that genomic typing may be useful to identify patients eligible for early alternative treatment to corticosteroid drugs.
|
9771216 |
1998 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Nonsignificant increases in DQA1 and DQB1 phenotype frequencies appeared to reflect known patterns of linkage disequilibrium with the HLA-DRB1 alleles associated with GCA and PMR groups.
|
9818656 |
1998 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Emerging data indicate that HLA-DRB1 genes represent important risk factors in giant cell arteritis.
|
7718419 |
1995 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
PMR and GCA share the associated sequence polymorphism encoded by the second hypervariable region (HVR) of the HLA-DRB1 gene.
|
8147928 |
1994 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Sequence comparison among the allelic products identified in the GCA cohort demonstrated heterogeneity for the sequence polymorphism of the third hypervariable region (HVR), but homology for the polymorphic residues within the HVR2 of the HLA-DRB1 gene.
|
1469092 |
1992 |