| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.080 | GeneticVariation | group | BEFREE | <b>Objective:</b> To evaluate if temporomandibular disorders (TMDs) are associated with genetic polymorphisms in <i>ESR1</i> and <i>ESR2</i>, which are genes encoding oestrogen receptor alpha (<i>ERα</i>) and beta (<i>ERβ</i>). | 31646926 | 2020 | ||||
|
0.080 | AlteredExpression | group | BEFREE | Previous studies showed elevated estrogen levels in subjects with TMJ disorders relative to controls and the presence of estrogen receptors α and β (ERα and ERβ) in TMJ fibrocartilage. | 29621430 | 2018 | ||||
|
0.080 | GeneticVariation | group | BEFREE | The TT (timin/timin) genotype for the ESR1 (rs2273206) gene was strongly associated with the risk of developing muscle TMDs and temporomandibular joint pain (P = .04). | 29175417 | 2018 | ||||
|
0.080 | GeneticVariation | group | BEFREE | ENPP1 and ESR1 genotypes associated with subclassifications of craniofacial asymmetry and severity of temporomandibular disorders. | 29103441 | 2017 | ||||
|
0.080 | GeneticVariation | group | BEFREE | ENPP1 and ESR1 genotypes influence temporomandibular disorders development and surgical treatment response in dentofacial deformities. | 27519661 | 2016 | ||||
|
0.080 | GeneticVariation | group | BEFREE | Studies have already pointed the association between TMD and genetic polymorphisms in the oestrogen receptor alpha, adrenergic receptor beta 2, serotonin receptor, serotonin transporter and catechol-O-methyltransferase genes, and other candidate genes continue to emerge. | 21536254 | 2011 | ||||
|
0.080 | GeneticVariation | group | BEFREE | The effects of estrogen receptor α polymorphism on the prevalence of symptomatic temporomandibular disorders. | 20656393 | 2010 | ||||
|
0.080 | GeneticVariation | group | BEFREE | This study suggests that a polymorphism in the estrogen receptor may increase the risk of women developing temporomandibular joint disorder. | 19411060 | 2009 |