Gene: FLT4 ×
Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2324
Gene Symbol: FLT4
FLT4 		0.540 GeneticVariation disease BEFREE Loss-of-function variants in FLT4 and KDR contribute substantially to the genetic basis of TOF. 30232381 2019
Entrez Id: 2324
Gene Symbol: FLT4
FLT4 		0.540 GeneticVariation disease BEFREE FLT4 variants were found in 2.4% (95% CI, 1.6%-3.8%) of TOF patients, with 21 patients harboring 22 unique, deleterious variants. 30582441 2019
Entrez Id: 2324
Gene Symbol: FLT4
FLT4 		0.540 Biomarker disease GENOMICS_ENGLAND Contribution of rare inherited and de novo variants in 2,871 congenital heart disease probands. 28991257 2017
Entrez Id: 2324
Gene Symbol: FLT4
FLT4 		0.540 Biomarker disease CTD_human Contribution of rare inherited and de novo variants in 2,871 congenital heart disease probands. 28991257 2017
Entrez Id: 2324
Gene Symbol: FLT4
FLT4 		0.540 GeneticVariation disease BEFREE Here, exome sequencing of a single cohort of 2,871 CHD probands, including 2,645 parent-offspring trios, implicated rare inherited mutations in 1.8%, including a recessive founder mutation in GDF1 accounting for ∼5% of severe CHD in Ashkenazim, recessive genotypes in MYH6 accounting for ∼11% of Shone complex, and dominant FLT4 mutations accounting for 2.3% of Tetralogy of Fallot. 28991257 2017
Entrez Id: 2324
Gene Symbol: FLT4
FLT4 		0.540 AlteredExpression disease BEFREE DNA microarray analysis revealed altered expression pattern for 236 genes including enhanced (1.5-2.2-fold) expression of angiogenic factors and their receptors including; VEGF, flt-1, flk-1 angiopoietin-2, FGF-2, FGF-R1, PDGF-A, whereas, flt-4, Tie, TGF-β, TGF-β3R showed decreased (1.6-3.4-fold) expression in ToF-patients. 23897578 2013