Compared with HIV-associated diffuse large B-cell lymphoma, PEL was associated with significant hypoalbuminemia (<i>P</i> < .0027), thrombocytopenia (<i>P</i> = .0045), and elevated IL-10 levels (<i>P</i> < .0001).
According to our data, patients with low producer type of IL-10 polymorphisms have more severe thrombocytopenia, suggesting that IL-10 gene polymorphisms may reflect the severity of ITP.
IL-10 serum levels and IL-10 promoter polymorphic genotype frequencies are not different between ITP cases and controls; however, in ITP patients, IL-10 promoter (1082 AA and 592 AA) genotypes and associated lower CD4, higher CD8, lower CD4/CD8 ratio is associated with more severe thrombocytopenia at presentation and had a poorer response to first-line treatment.
The results showed that after treatment, the number of Treg cells was increased, the number of Th17 cells was decreased, the levels of anti-inflammatory factors IL-10 and TGF-β were increased, and levels of pro-inflammatory factors IL-17, IL-21 and IL-22 were decreased in chronic hepatitis B patients combined with thrombocytopenia, indicating the decreased autoimmune response and improved thrombocytopenia.
A subset of cytokines consisting of IL-1β, IL-8, IL-6, TNF-α, and IL-10 was also coordinately high and significantly associated with severity of thrombocytopenia in HA patients.
In the seven children who developed shock with NPMODS compared to eight patients with shock without NPMODS and 12 patients with severe sepsis only, we found more profound coagulopathy [thrombocytopenia (<i>p</i> = 0.04), elevated INR (<i>p</i> = 0.038), low fibrinogen level (<i>p</i> = 0.049), and low TEG-G value (<i>p</i> = 0.01)] and higher peak of interleukin-6 (<i>p</i> = 0.0014) and IL-10 (<i>p</i> = 0.007).