Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
0.360 | Biomarker | phenotype | BEFREE | While the granulocyte colony stimulating factors (G-CSF) filgrastim (Neupogen<sup>®</sup>), pegfilgrastim (Neulasta<sup>®</sup>), and sargramostim (Leukine<sup>®</sup>) are approved to increase survival in patients exposed to a myelosuppressive dose of radiation, no medical countermeasure is currently available for treatment of the thrombocytopenia that also results following radiation exposure. | 31021662 | 2020 | ||||
|
0.360 | Biomarker | phenotype | BEFREE | While mild thrombocytopenia is common in allogeneic peripheral blood stem cell transplant donors after G-CSF mobilization, serious thrombocytopenia is rarely reported. | 30896621 | 2019 | ||||
|
0.360 | Biomarker | phenotype | BEFREE | Collectively, G-CSF administration can result in thrombocytopenia in hematopoietic stem cell donors and exacerbate existing thrombocytopenia in transplantation recipients. | 31473203 | 2019 | ||||
|
0.360 | Biomarker | phenotype | BEFREE | Her clinical course was complicated by the development of neutropenia, requiring granulocyte colony-stimulating factor, and thrombocytopenia, requiring intermittent platelet transfusions, with later development of B acute lymphoblastic leukemia 2 years after initial presentation. | 30904992 | 2019 | ||||
|
0.360 | Biomarker | phenotype | BEFREE | Grade 3/4 neutropenia was seen in 15 (35%) patients, nine (21%) required prophylactic granulocyte colony-stimulating factor, 13 (30%) patients had grade 3/4 thrombocytopenia. | 30587629 | 2019 | ||||
|
0.360 | Biomarker | phenotype | CTD_human | Alternating dose-dense chemotherapy in patients with high volume disseminated non-seminomatous germ cell tumours. | 12085204 | 2002 | ||||
|
0.360 | Biomarker | phenotype | BEFREE | Attempts to further escalate the dose using 5 microg/kg granulocyte colony-stimulating factor proved unsuccessful because of thrombocytopenia. | 11895897 | 2002 | ||||
|
0.360 | Biomarker | phenotype | CTD_human | High-dose paclitaxel with granulocyte colony-stimulating factor in patients with advanced breast cancer refractory to anthracycline therapy: a European Cancer Center trial. | 7543699 | 1995 |