Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 22852
Gene Symbol: ANKRD26
ANKRD26
0.200 GeneticVariation phenotype BEFREE Regardless of age of presentation and severity of symptoms related to thrombocytopenia and/or platelet dysfunction, a subset of patients with IT are at increased risk of developing myeloid neoplasms during their life time, particularly those with germline autosomal dominant mutations in RUNX1, ANKRD26, and ETV6. 31069978 2019
Entrez Id: 22852
Gene Symbol: ANKRD26
ANKRD26
0.200 GeneticVariation phenotype CLINVAR Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders. 31064749 2019
Entrez Id: 22852
Gene Symbol: ANKRD26
ANKRD26
0.200 Biomarker phenotype BEFREE The overall purpose of this review is to point out that important progresses have been made in understanding the pathogenesis of ANKRD26-Related Thrombocytopenia and MYH9-Related Diseases and new therapeutic approaches have been proposed and tested. 29545013 2018
Entrez Id: 22852
Gene Symbol: ANKRD26
ANKRD26
0.200 Biomarker phenotype BEFREE ANKRD26-related thrombocytopenia and thrombosis are rare. 28698781 2017
Entrez Id: 22852
Gene Symbol: ANKRD26
ANKRD26
0.200 GeneticVariation phenotype BEFREE Since the dominant thrombocytopenias due to mutations in RUNX1 and ANKRD26 are also characterized by normal platelet size and predispose to hematologic malignancies, we suggest that screening for ETV6, RUNX1 and ANKRD26 mutations should be performed in all subjects with autosomal dominant thrombocytopenia and normal platelet size. 27365488 2016
Entrez Id: 22852
Gene Symbol: ANKRD26
ANKRD26
0.200 GeneticVariation phenotype BEFREE Clinical and laboratory characteristics in congenital ANKRD26 mutation-associated thrombocytopenia: A detailed phenotypic study of a family. 27123948 2016
Entrez Id: 22852
Gene Symbol: ANKRD26
ANKRD26
0.200 Biomarker phenotype BEFREE Here, we identified underlying mechanisms of ANKRD26-associated thrombocytopenia. 24430186 2014
Entrez Id: 22852
Gene Symbol: ANKRD26
ANKRD26
0.200 Biomarker phenotype BEFREE Moreover, we describe four recently identified disorders that belong to this group of disorders that are often diagnosed in adults: MYH9-related disease, monoallelic Bernard-Soulier syndrome, ANKRD26-related thrombocytopenia, and familial platelet disorder with predisposition to acute leukemia. 23510089 2013
Entrez Id: 22852
Gene Symbol: ANKRD26
ANKRD26
0.200 GeneticVariation phenotype BEFREE In the last 5 years, nine new genes whose mutations are responsible for thrombocytopenia have been identified, and this also led to the recognition of several novel nosographic entities, such as thrombocytopenias deriving from mutations in CYCS, TUBB1, FLNA, ITGA2B/ITGB3, ANKRD26 and ACTN1. 23636669 2013
Entrez Id: 22852
Gene Symbol: ANKRD26
ANKRD26
0.200 Biomarker phenotype BEFREE This review summarizes the general aspects of inherited thrombocytopenias and describes in more detail MYH9-related diseases (encompassing four thrombocytopenias previously recognized as separate diseases) and the recently described ANKRD26-related thrombocytopenia, which are among the most frequent forms of inherited thrombocytopenia. 22972471 2012
Entrez Id: 22852
Gene Symbol: ANKRD26
ANKRD26
0.200 Biomarker phenotype BEFREE Platelets in THC2-linked thrombocytopenia appear to be normal in size and function although bone marrow morphology reveals a lack of mature, polyploid megakaryocytes. 22102272 2011
Entrez Id: 22852
Gene Symbol: ANKRD26
ANKRD26
0.200 Biomarker phenotype BEFREE Available data from an animal model and Dr. Watson's genome give evidence against haploinsufficiency as the pathogenetic mechanism for ANKRD26-mediated thrombocytopenia. 21211618 2011
Entrez Id: 22852
Gene Symbol: ANKRD26
ANKRD26
0.200 GeneticVariation phenotype BEFREE Analysis of all 21 families with ANKRD26 mutations identified to date revealed that thrombocytopenia and bleeding tendency were usually mild. 21467542 2011
Entrez Id: 22852
Gene Symbol: ANKRD26
ANKRD26
0.200 Biomarker phenotype HPO