Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.060 GeneticVariation phenotype BEFREE In the seven children who developed shock with NPMODS compared to eight patients with shock without NPMODS and 12 patients with severe sepsis only, we found more profound coagulopathy [thrombocytopenia (<i>p</i> = 0.04), elevated INR (<i>p</i> = 0.038), low fibrinogen level (<i>p</i> = 0.049), and low TEG-G value (<i>p</i> = 0.01)] and higher peak of interleukin-6 (<i>p</i> = 0.0014) and IL-10 (<i>p</i> = 0.007). 31681719 2019
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.060 Biomarker phenotype BEFREE The clinical course suggests that 2 factors, including overproduction of interleukin 6 and autoimmune-mediated thrombocytopenia via thrombopoietin receptor, may have contributed to the pathogenesis of TAFRO syndrome in this patient. 29626596 2018
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.060 Biomarker phenotype BEFREE Furthermore, the presence of each or both high-producing genotypes [TNF: p = 0.048, odds ratio (OR): 3.979; IL6: p = 0.001, OR: 6.835; both: p = 0.010, OR: 6.068] and thrombocytopenia at platelet counts of <50,000/μL (p = 0.004, OR: 4.857) were independently associated with an increased risk of manifesting a hemoglobin level of <8 g/dL at diagnosis. 28601896 2017
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.060 Biomarker phenotype BEFREE In sharp contrast to intravenous injections, direct hepatic injections neither raised serum IL-6 nor resulted in thrombocytopenia. 23947957 2013
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.060 Biomarker phenotype BEFREE Plasma concentrations of proinflammatory cytokines TNF-α and IL-6 are elevated by thrombocytopenia and decreased by platelet transfusion in septic mice. 24150174 2013
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.060 GeneticVariation phenotype BEFREE The frequency of the IL-6-634 GC and GG genotypes was significantly higher in patients with grades 1-4 leukopenia (P=0.003; Crude-odds ratios (Cr-OR) =4.0), neutropenia (P=0.0051; Cr-OR=3.6), or thrombocytopenia (P<0.0001; Cr-OR=6.1) than in patients without these toxicities. 16820919 2006