Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5196
Gene Symbol: PF4
PF4
0.400 Biomarker phenotype BEFREE Heparins interact with platelet factor 4 (PF4), which can induce an immune response causing thrombocytopenia. 31573759 2020
Entrez Id: 5196
Gene Symbol: PF4
PF4
0.400 Biomarker phenotype BEFREE Conditional <i>Scl</i> knockout (KO) mice crossed with transgenic mice expressing Cre recombinase under the control of the mouse platelet factor 4 (<i>Pf4</i>) promoter generated megakaryocytes with markedly reduced but not absent <i>Scl</i> These <i>Pf4Sclc</i>-KO mice had mild thrombocytopenia and subtle defects in platelet aggregation. 31300405 2019
Entrez Id: 5196
Gene Symbol: PF4
PF4
0.400 Biomarker phenotype BEFREE Heparin-induced thrombocytopaenia was second diagnosed because of persistent severe thrombocytopaenia after 2 weeks of treatment associated with positive conversion of antibodies against platelet factor 4, and a positive functional assay. 31527216 2019
Entrez Id: 5196
Gene Symbol: PF4
PF4
0.400 AlteredExpression phenotype BEFREE Finally, IdeS prevented thrombocytopenia and hypercoagulability induced by 5B9 with heparin in transgenic mice expressing human PF4 and FcγRIIA receptors. 30917957 2019
Entrez Id: 5196
Gene Symbol: PF4
PF4
0.400 AlteredExpression phenotype BEFREE This glycopolymer was further examined for cross-bioactivity using a solution-based competitive biolayer interferometry assay with other HS-binding proteins (growth factors, P-selectin, and platelet factor 4), which are responsible for mediating angiogenic activity, cell metastasis, and antibody-induced thrombocytopenia. 30543095 2019
Entrez Id: 5196
Gene Symbol: PF4
PF4
0.400 GeneticVariation phenotype BEFREE The purpose of this study was to investigate the prevalence of posttransplant thrombocytopenia and its association with other clinical conditions and genetic polymorphisms of SDF1 and PF4 genes a long time after transplantation. 31009686 2019
Entrez Id: 5196
Gene Symbol: PF4
PF4
0.400 AlteredExpression phenotype BEFREE Even though the degree of thrombocytopenia and platelet activation were similar between dengue-infected and HIV plus dengue-coinfected patients, plasma levels of the platelet-derived chemokines RANTES/CCL5 and PF4/CXCL4 were lower in coinfection. 31068600 2019
Entrez Id: 5196
Gene Symbol: PF4
PF4
0.400 Biomarker phenotype BEFREE Our study suggests that patients with thrombocytopenia testing negative for anti-PF4-heparin may still harbor antibodies to platelets. 31107976 2019
Entrez Id: 5196
Gene Symbol: PF4
PF4
0.400 Biomarker phenotype BEFREE Here we show that the expression of PF4 on platelets and development of thrombocytopenia are modulated by the (re)distribution of PF4 among hematopoietic and endothelial cell surfaces. 29914979 2018
Entrez Id: 5196
Gene Symbol: PF4
PF4
0.400 Biomarker phenotype BEFREE Immediately postoperatively, while treated with unfractionated heparin, the patient developed thrombocytopaenia with positive platelet factor 4 antibodies and an abnormal serotonin functional platelet assay, consistent with heparin-induced thrombocytopaenia. 30323102 2018
Entrez Id: 5196
Gene Symbol: PF4
PF4
0.400 Biomarker phenotype BEFREE HIT diagnosis is established by recognizing thrombocytopenia and/or thrombosis in an affected patient and from the results of serological tests such as the platelet factor 4 (PF4)/heparin immunoassay (PF4 ELISA) and serotonin release assay (SRA). 28991552 2017
Entrez Id: 5196
Gene Symbol: PF4
PF4
0.400 Biomarker phenotype BEFREE However, the effect of platelet factor 4-cre on plasma FXIII-A was exerted outside of the megakaryocyte lineage because plasma FXIII-A was not reduced in the Mpl<sup>-/-</sup> mouse, despite marked thrombocytopenia. 28596376 2017
Entrez Id: 5196
Gene Symbol: PF4
PF4
0.400 Biomarker phenotype BEFREE HIT is characterized by an acute, transient prothrombotic state combined with thrombocytopenia and is caused by platelet-activating IgG antibodies that bind to complexes of heparin and platelet factor 4. 28262567 2017
Entrez Id: 5196
Gene Symbol: PF4
PF4
0.400 Biomarker phenotype BEFREE With immunohistochemistry, we examined in vivo free PF4 in murine bone marrow before and after radiation injury and in the setting of megakaryocytopenia and thrombocytopenia. 26256688 2015
Entrez Id: 5196
Gene Symbol: PF4
PF4
0.400 Biomarker phenotype CTD_human Heparin-induced thrombocytopenia. 20162249 2010
Entrez Id: 5196
Gene Symbol: PF4
PF4
0.400 Biomarker phenotype CTD_human Delayed-onset heparin-induced thrombocytopenia is caused by immunoglobulin G antibodies that are reactive against the heparin-platelet factor 4 complex in the absence of circulating heparin. 15795722 2005
Entrez Id: 5196
Gene Symbol: PF4
PF4
0.400 Biomarker phenotype LHGDN Defining a second epitope for heparin-induced thrombocytopenia/thrombosis antibodies using KKO, a murine HIT-like monoclonal antibody. 11830470 2002
Entrez Id: 5196
Gene Symbol: PF4
PF4
0.400 Biomarker phenotype CTD_human Heparin-induced thrombocytopenia/thrombosis in a transgenic mouse model requires human platelet factor 4 and platelet activation through FcgammaRIIA. 11588041 2001
Entrez Id: 5196
Gene Symbol: PF4
PF4
0.400 Biomarker phenotype CTD_human Complexes of heparin and platelet factor 4 specifically stimulate T cells from patients with heparin-induced thrombocytopenia/thrombosis. 10381515 1999
Entrez Id: 5196
Gene Symbol: PF4
PF4
0.400 Biomarker phenotype CTD_human Antibodies from patients with heparin-induced thrombocytopenia/thrombosis recognize different epitopes on heparin: platelet factor 4. 9446652 1998
Entrez Id: 5196
Gene Symbol: PF4
PF4
0.400 Biomarker phenotype CTD_human Pathogenicity of human anti-platelet factor 4 (PF4)/heparin in vivo: generation of mouse anti-PF4/heparin and induction of thrombocytopenia by heparin. 9158107 1997
Entrez Id: 5196
Gene Symbol: PF4
PF4
0.400 Biomarker phenotype CTD_human These findings indicate that antibodies associated with HITP react with PF4 complexed with heparin in solution or with glycosaminoglycan molecules on the surface of endothelial cells and provide the basis for a new hypothesis to explain the development of thrombocytopenia with thrombosis or disseminated intravascular coagulation in patients sensitive to heparin. 8282825 1994