Gene: UGT1A1 ×
Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 54658
Gene Symbol: UGT1A1
UGT1A1 		0.050 GeneticVariation phenotype BEFREE The relationship between UGT1A1 polymorphisms and first-cycle neutropenia as well as thrombocytopenia was evaluated. 30328531 2019
Entrez Id: 54658
Gene Symbol: UGT1A1
UGT1A1 		0.050 GeneticVariation phenotype BEFREE Two common polymorphisms (UGT1A1*28 and UGT1A1*60) were previously associated with impaired drug clearance and thrombocytopenia risk, likely from increased drug exposure. 29951694 2018
Entrez Id: 54658
Gene Symbol: UGT1A1
UGT1A1 		0.050 GeneticVariation phenotype BEFREE Furthermore, both UGT1A1*28 and *60 variants were associated with increased incidence of thrombocytopenia and neutropenia. 26773202 2016
Entrez Id: 54658
Gene Symbol: UGT1A1
UGT1A1 		0.050 GeneticVariation phenotype BEFREE Belinostat AUC was increased (P = .003), and t1/2 increased (P = .0009) in UGT1A1*28 and UGT1A1*60 carriers who received more than 400 mg/m(2) /24 h. The incidence of grades 3-4 thrombocytopenia (P = .0081) was associated with UGT1A1 polymorphisms. 26313268 2016
Entrez Id: 54658
Gene Symbol: UGT1A1
UGT1A1 		0.050 Biomarker phenotype BEFREE Patients homozygous for UGT1A1*28 had more grade 4 thrombocytopenia (80% vs 37%; P=0.14). 25602966 2015