Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.080 GeneticVariation phenotype BEFREE Furthermore, the presence of each or both high-producing genotypes [TNF: p = 0.048, odds ratio (OR): 3.979; IL6: p = 0.001, OR: 6.835; both: p = 0.010, OR: 6.068] and thrombocytopenia at platelet counts of <50,000/μL (p = 0.004, OR: 4.857) were independently associated with an increased risk of manifesting a hemoglobin level of <8 g/dL at diagnosis. 28601896 2017
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.080 Biomarker phenotype BEFREE A subset of cytokines consisting of IL-1β, IL-8, IL-6, TNF-α, and IL-10 was also coordinately high and significantly associated with severity of thrombocytopenia in HA patients. 28628633 2017
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.080 Biomarker phenotype BEFREE Prospective cohort study comparing children with severe sepsis and any of three phenotypes: 1) immunoparalysis-associated multiple organ failure (whole blood ex vivo tumor necrosis factor response to endotoxin < 200 pg/mL), 2) thrombocytopenia-associated multiple organ failure (new onset thrombocytopenia with acute kidney injury and a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 activity < 57%), and/or 3) sequential multiple organ failure with hepatobiliary dysfunction (respiratory distress followed by liver dysfunction with soluble Fas ligand > 200 pg/mL), to those without any of these phenotypes. 28410274 2017
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.080 Biomarker phenotype BEFREE Plasma concentrations of proinflammatory cytokines TNF-α and IL-6 are elevated by thrombocytopenia and decreased by platelet transfusion in septic mice. 24150174 2013
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.080 GeneticVariation phenotype BEFREE Furthermore, Rn significantly decreased the production of tumor necrosis factor-α (TNF-a), interleukin (IL)-6, -1β and -10 and attenuated cardiovascular dysfunction, including blood pressure and heart pulse, and thrombocytopenia in LPS-induced endotoxemic mice. 21143376 2011
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.080 Biomarker phenotype BEFREE The presence of -308A TNFα is associated with anemia and thrombocytopenia in patients with myelodysplastic syndromes. 21983349 2011
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.080 GeneticVariation phenotype BEFREE Similarly, the frequency of the IL-1beta-511 TC and TT genotypes and the frequency of the TNF-alpha-1031 TT genotype were significantly higher in patients with grades 1-4 thrombocytopenia (P=0.015; Cr-OR=2.9) and stomatitis (P=0.02; Cr-OR=3.1), respectively. 16820919 2006
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.080 AlteredExpression phenotype BEFREE Platelet Toll-like receptor expression modulates lipopolysaccharide-induced thrombocytopenia and tumor necrosis factor-alpha production in vivo. 16179373 2006