Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.010 Biomarker disease BEFREE While Mo-MuLV only induced Thy-1+ thymomas, v-abl- and BCR-ABL-induced thymomas often contained mixed populations of B220+ and Thy-1+ lymphocytes in the same tumor. 8396667 1993
Entrez Id: 154
Gene Symbol: ADRB2
ADRB2
0.010 GeneticVariation disease BEFREE Gene polymorphisms of β2-AR on positions 16 and 27 showed no significant difference between relapsed and non-relapsed MG patients with thymus abnormality (thymus hyperplasia: position 16, p = 0.792; position 27, p = 0.664; thymoma: position 16, p = 0.226; position 27, p = 0.615). 27338803 2017
Entrez Id: 54806
Gene Symbol: AHI1
AHI1
0.010 Biomarker disease BEFREE A panel of thymomas induced by intrathymic injection of Mo-MuLV, Abelson murine leukemia virus (A-MuLV), or the bcr-abl/M virus was analyzed for proviral integration near c-myc, N-myc, Pim-1, and Mlvi-1 loci that are frequently occupied by provirus in Mo-MuLV-induced T cell lymphomas, and for integration near Ahi-1 that is often occupied in A-MuLV/M-induced pre-B cell lymphoma. 9204986 1997
Entrez Id: 10598
Gene Symbol: AHSA1
AHSA1
0.010 AlteredExpression disease BEFREE In experimental models of disease, the carotenoid astaxanthin has been shown to modulate autophagy by regulating signaling pathways, including the AMP-activated protein kinase (AMPK), cellular homolog of murine thymoma virus akt8 oncogene (Akt), and mitogen-activated protein kinase (MAPK), such as c-Jun N-terminal kinase (JNK) and p38. 31547619 2019
Entrez Id: 7965
Gene Symbol: AIMP2
AIMP2
0.010 AlteredExpression disease BEFREE In experimental models of disease, the carotenoid astaxanthin has been shown to modulate autophagy by regulating signaling pathways, including the AMP-activated protein kinase (AMPK), cellular homolog of murine thymoma virus akt8 oncogene (Akt), and mitogen-activated protein kinase (MAPK), such as c-Jun N-terminal kinase (JNK) and p38. 31547619 2019
Entrez Id: 326
Gene Symbol: AIRE
AIRE
0.090 Biomarker disease BEFREE To test whether these parallels extend further, we screened 247 patients with MG, thymoma, or both for clinical features and organ-specific autoantibodies characteristic of APS-I patients, and we assayed 26 thymoma samples for transcripts for AIRE and 16 peripheral tissue-specific autoantigens (TSAgs) by quantitative PCR. 25230752 2014
Entrez Id: 326
Gene Symbol: AIRE
AIRE
0.090 Biomarker disease BEFREE The very recently discovered neutralizing autoantibodies (autoAbs) against Th17-related cells and cytokines in two autoimmunity-related syndromes associated with AIRE-mutant thymi or AIRE-deficient thymomas help to explain the chronic mucocutaneous candidiasis (CMC) seen in both syndromes. 21574164 2011
Entrez Id: 326
Gene Symbol: AIRE
AIRE
0.090 Biomarker disease BEFREE Neutralising titres against type I IFNs averaged even higher in patients with APS1 than in patients with thymomas. 16784312 2006
Entrez Id: 326
Gene Symbol: AIRE
AIRE
0.090 GeneticVariation disease BEFREE Recently, we also found that expression of the autoimmune regulator (AIRE) gene is absent from approximately 95% of thymomas. 18567864 2008
Entrez Id: 326
Gene Symbol: AIRE
AIRE
0.090 AlteredExpression disease BEFREE We studied AIRE mRNA in 45 thymomas and three normal thymi using quantitative reverse transcription polymerase chain reaction (RT-PCR). 18568643 2008
Entrez Id: 326
Gene Symbol: AIRE
AIRE
0.090 AlteredExpression disease BEFREE Expression of the autoimmune regulator gene (AIRE) and the presence of CD25(+)/forkhead box p3 (FoxP3)(+) T regulatory (T(reg)) cells were investigated in histologically normal adult thymi and in thymomas using immunohistochemistry and quantitative real-time polymerase chain reaction (PCR). 17590173 2007
Entrez Id: 326
Gene Symbol: AIRE
AIRE
0.090 AlteredExpression disease BEFREE The objective of this study was to examine the levels of AIRE, AchR, and Foxp3 expression in thymomas. 24768600 2014
Entrez Id: 326
Gene Symbol: AIRE
AIRE
0.090 GeneticVariation disease BEFREE There must be further clues in the intriguing serological and cellular parallels in some patients with late-onset MG but without thymomas-and in others with AIRE mutations-and in the contrasts with early-onset MG, as discussed here. 20380583 2010
Entrez Id: 326
Gene Symbol: AIRE
AIRE
0.090 Biomarker disease BEFREE This is why we checked LOMG patients for two further peculiar features of TAMG - its associations with the CTLA4(high/gain-of-function) +49A/A genotype and with increased thymic export of naïve T cells into the blood, possibly after defective negative selection in AIRE-deficient thymomas. 24373506 2014
Entrez Id: 207
Gene Symbol: AKT1
AKT1
0.100 AlteredExpression disease BEFREE We analyzed mutations in FGFR3, phosphoinositide 3 kinase catalytic alpha polypeptide (PIK3CA), v-akt murine thymoma viral oncogene homolog 1 (AKT1), v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS), v-Ha-ras Harvey rat sarcoma viral oncogene homolog (HRAS), and v-raf murine sarcoma viral oncogene homolog B1 (BRAF) in 88 urothelial cell carcinomas and the immunohistochemical expression of phospho-v-akt murine thymoma viral oncogene homolog (AKT) and mitogen-activated protein kinase 1 and 2 (pERK1/2) in 80 and 77 urothelial cell carcinomas, respectively. 22417847 2012
Entrez Id: 207
Gene Symbol: AKT1
AKT1
0.100 Biomarker disease BEFREE Elevated AKT (v-akt murine thymoma viral oncogene homolog) activity was demonstrated to increase ETS1 protein levels specifically in castrate-resistant cells and exogenous ETS1 expression was sufficient to rescue invasive potential decreased by inhibition of AKT activity. 22232738 2012
Entrez Id: 207
Gene Symbol: AKT1
AKT1
0.100 Biomarker disease BEFREE In BCAR4-expressing cells, phosphorylation of v-erb-b2 erythroblastic leukaemia viral oncogene homolog (ERBB)2, ERBB3, and their downstream mediators extracellular signal-regulated kinase 1/2 and v-akt murine thymoma viral oncogene homolog (AKT) 1/2, was increased. 20859285 2010
Entrez Id: 207
Gene Symbol: AKT1
AKT1
0.100 Biomarker disease BEFREE The survival of CSF1R(pos) cells requires active AKT (v-akt murine thymoma viral oncogene homolog 1) signaling, which contributed to increased levels of nuclear, transcriptionally competent β-catenin. 24722292 2014
Entrez Id: 207
Gene Symbol: AKT1
AKT1
0.100 Biomarker disease BEFREE Epidermal growth factor receptor (EGFR), a receptor tyrosine kinase that activates multiple signaling pathways, including phosphatidylinositol-3-kinase/v-AKT murine thymoma viral oncogene homolog protein (Akt), has long been a target of novel therapies. 19378324 2009
Entrez Id: 207
Gene Symbol: AKT1
AKT1
0.100 Biomarker disease BEFREE The present study investigated, for the first time in the rabbit model, the effect of adding α-tocopherol (0, 100, 200 and 400µM) during IVM on putative transcripts involved in antioxidant defence (superoxide dismutase 2, mitochondrial (SOD2), glutathione peroxidase 1 (GPX1), catalase (CAT)), cell cycle regulation and apoptosis cascade (apoptosis tumour protein 53 (TP53), caspase 3, apoptosis-related cysteine protease (CASP3)), cell cycle progression (cellular cycle V-Akt murine thymoma viral oncogene homologue 1 (AKT1)), cumulus expansion (gap junction protein, alpha 1, 43 kDa (GJA1) and prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclo-oxygenase) (PTGS2)) and metabolism (glucose-6-phosphate dehydrogenase (G6PD)). 29966585 2018
Entrez Id: 207
Gene Symbol: AKT1
AKT1
0.100 Biomarker disease BEFREE The protein kinase v-akt murine thymoma viral oncogene homolog (AKT) gene family comprises three human homologs that phosphorylate and inactivate glycogen synthase kinase 3beta (GSK3beta). 16987250 2006
Entrez Id: 207
Gene Symbol: AKT1
AKT1
0.100 Biomarker disease BEFREE These insulin enhancement effects were associated with increased expression of peroxisome proliferator-activated receptor α and γ (PPARα/γ) in fat, activation of Akt (v-Akt murine thymoma viral oncogene)/PKB (protein kinase-B) in fat and liver, and inactivation of c-Jun NH<sub>2</sub>-terminal protein kinases (JNK) in liver. 28709620 2017
Entrez Id: 207
Gene Symbol: AKT1
AKT1
0.100 Biomarker disease BEFREE Eight different genetic loci, including 1-acylglycerol-3-phosphate-O-acyltransferase 2, Berardinelli-Seip congenital lipodystrophy 2, caveolin 1, lamin A/C, peroxisome proliferator-activated receptor gamma, v-AKT murine thymoma oncogene homolog 2, zinc metalloprotease and lipase maturation factor 1 have been described linked to different lipodystrophy syndromes. 19494770 2009
Entrez Id: 207
Gene Symbol: AKT1
AKT1
0.100 Biomarker disease BEFREE Signalling was tested in three EGFR expressing UM cell lines by Western blotting using phosphorylation specific antibodies for EGFR and the downstream mediators AKT (v-akt murine thymoma viral oncogene homolog) and extracellular signal-regulated kinase (ERK). 23849826 2013
Entrez Id: 208
Gene Symbol: AKT2
AKT2
0.010 Biomarker disease BEFREE These insulin enhancement effects were associated with increased expression of peroxisome proliferator-activated receptor α and γ (PPARα/γ) in fat, activation of Akt (v-Akt murine thymoma viral oncogene)/PKB (protein kinase-B) in fat and liver, and inactivation of c-Jun NH<sub>2</sub>-terminal protein kinases (JNK) in liver. 28709620 2017