Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1493
Gene Symbol: CTLA4
CTLA4
0.060 AlteredExpression disease BEFREE Furthermore, we evaluated the relationship between CTLA-4 expression and the clinical-pathologic characteristics and prognosis in patients with thymomas. 29682176 2018
Entrez Id: 1493
Gene Symbol: CTLA4
CTLA4
0.060 GeneticVariation disease BEFREE A predisposing effect of rs1863800*C, rs733618*C, and rs231775*G of CTLA4 gene to general risk of MG in Chinese was demonstrated for the first time, which was likely derived from EOMG, SPMG, MG without thymoma and the female patients. 25003519 2014
Entrez Id: 1493
Gene Symbol: CTLA4
CTLA4
0.060 GeneticVariation disease BEFREE This is why we checked LOMG patients for two further peculiar features of TAMG - its associations with the CTLA4(high/gain-of-function) +49A/A genotype and with increased thymic export of naïve T cells into the blood, possibly after defective negative selection in AIRE-deficient thymomas. 24373506 2014
Entrez Id: 1493
Gene Symbol: CTLA4
CTLA4
0.060 GeneticVariation disease LHGDN The unusual disease association with a CTLA4high genotype implies a unique pathogenesis of paraneoplastic MG, with high CTLA4 levels possibly supporting the nontolerogenic selection of CD4+ T cells in MG-associated thymomas. 16178018 2005
Entrez Id: 1493
Gene Symbol: CTLA4
CTLA4
0.060 AlteredExpression disease BEFREE The unusual disease association with a CTLA4high genotype implies a unique pathogenesis of paraneoplastic MG, with high CTLA4 levels possibly supporting the nontolerogenic selection of CD4+ T cells in MG-associated thymomas. 16178018 2005
Entrez Id: 1493
Gene Symbol: CTLA4
CTLA4
0.060 GeneticVariation disease BEFREE We previously reported that alleles with longer PCR products (designated as allele xx) in an (AT)n polymorphism in Ctla-4 are associated with myasthenia gravis with thymoma, while the shortest allele, 86, is negatively associated with the disease. 10713366 2000
Entrez Id: 1493
Gene Symbol: CTLA4
CTLA4
0.060 Biomarker disease BEFREE Here we describe an association of Ctla-4 gene to the disease with thymoma and a higher prevalence of CTLA-4 gene polymorphism allele 104 in patients positive for IL-1beta TaqI allele 2, an IL-1beta 'high secretor' phenotype. 9688341 1998