Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
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0.070 | Biomarker | group | BEFREE | Electrochemical measurement of membrane cholesterol in mouse trachea and in primary human CF bronchial epithelial cells is used to monitor CFTR correction and manipulation of cholesterol processing by HDAC6 inhibition. | 29941319 | 2019 | ||||
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0.070 | Biomarker | group | BEFREE | A/J mice expressing wild type CFTR (+/+) were exposed to cigarette smoke or air with or without roflumilast and the effect of treatment on CFTR-dependent chloride transport was quantified using nasal potential difference (NPD) measurements in vivo and short-circuit current (Isc) analysis of trachea ex vivo. | 28923049 | 2017 | ||||
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0.070 | Biomarker | group | BEFREE | CFTR colocalizes with ZO-1 at the tight junctions of trachea and epididymis, and is expressed before ZO-1 in Wolffian ducts. | 25107366 | 2014 | ||||
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0.070 | AlteredExpression | group | BEFREE | Conversely, in mouse trachea, low levels of CFTR failed to suppress Liddle ENaC hyperfunction. | 20566636 | 2010 | ||||
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0.070 | Biomarker | group | BEFREE | To test this hypothesis, we examined the expression of Cl(-)/HCO(3)(-) exchangers in tracheal epithelial cells exhibiting physiological features prototypical of cystic fibrosis [CFT-1 cells, lacking a functional cystic fibrosis transmembrane conductance regulator (CFTR)] or normal trachea (CFT-1 cells transfected with functional wild-type CFTR, termed CFT-WT). | 10898717 | 2000 | ||||
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0.070 | Biomarker | group | BEFREE | However, the extent of the complementation in vivo by wild-type virus is limited because no additional spreading or shedding of Ad-CFTR to trachea, lungs, and stools is elicited. | 7548271 | 1995 | ||||
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0.070 | Biomarker | group | BEFREE | Using this vector, the normal human CFTR cDNA has been successfully transferred to airway epithelial cells of experimental animals via the trachea. | 7517653 | 1994 |