Vice versa, 7-DHC pretreatment of the isolated trachea leads to a TRPA1- and TRPV1-dependent increase of the light-induced calcitonin gene-related peptide release.
In the present study, the TRPV1 transcript was detected by RT-PCR in primary cultured human ASM cells, and the TRPV1 protein was detected in ASM of human trachea by immunohistochemistry.
Treating the trachea with BDNF, to activate the TRKB receptors, caused a phenotypic change in the vast majority of nodose Aδ neurons such that they expressed TRPV1.