A Novel Genetic Variation in <i>NCF2</i>, the Core Component of NADPH Oxidase, Contributes to the Susceptibility of Tuberculosis in Western Chinese Han Population.
Altogether, this study suggests that PPE2 inhibits NADPH oxidase-mediated ROS production to favor <i>M. tuberculosis</i> survival in macrophages.The findings that <i>M. tuberculosis</i> PPE2 protein is involved in the modulation of oxidative response in macrophages will help us in improving our knowledge of host-pathogen interactions and the application of better therapeutics against tuberculosis.