Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3431
Gene Symbol: SP110
SP110
0.100 GeneticVariation disease BEFREE We made a minireview on the association of many candidate genes with TB based on recent research studies systematically, such as the human leukocyte antigen (HLA) gene, the solute carrier family 11 member 1 (SLC11A1) gene system, the vitamin D receptor (VDR) gene, the mannan-binding lectin (MBL) gene, the nitric oxide synthase 2A (NOS2A) gene, the speckled 110 (SP110) gene, and the P2X7 receptor (P2X7) gene. 31485302 2019
Entrez Id: 3431
Gene Symbol: SP110
SP110
0.100 GeneticVariation disease BEFREE Certain Polymorphisms in SP110 Gene Confer Susceptibility to Tuberculosis: A Comprehensive Review and Updated Meta-Analysis. 27873510 2017
Entrez Id: 3431
Gene Symbol: SP110
SP110
0.100 Biomarker disease BEFREE Moreover, genetic studies in patients suggest that SP110 plays a key role in modulating TB susceptibility in concert with NFκB1 and TNFα genes. 27858493 2017
Entrez Id: 3431
Gene Symbol: SP110
SP110
0.100 Biomarker disease BEFREE For example, the CD163 gene-edited pig is resistant to porcine reproductive and respiratory syndrome (PRRS, also referred to as "blue ear disease"), and a SP110 gene knock-in cow less susceptible to tuberculosis. 29094286 2017
Entrez Id: 3431
Gene Symbol: SP110
SP110
0.100 GeneticVariation disease BEFREE We found that the "GC" haplotype in SP110 was protective against TB, with a 64% reduction in disease risk. 27623071 2016
Entrez Id: 3431
Gene Symbol: SP110
SP110
0.100 Biomarker disease BEFREE To investigate the effects of SP110 and its associated genes, i.e., MYBBP1A and RELA, on pathological progression of MTB infection, an association study with 424 patients of fresh pulmonary tuberculosis (PTB) and 424 healthy controls was performed. 25612917 2016
Entrez Id: 3431
Gene Symbol: SP110
SP110
0.100 Biomarker disease BEFREE Here, we report site-specific knockin of the transcription activator-like effector (TALE) nickase-mediated SP110 nuclear body protein gene (SP110) via homologous recombination to produce tuberculosis-resistant cattle. 25733846 2015
Entrez Id: 3431
Gene Symbol: SP110
SP110
0.100 Biomarker disease BEFREE Genetic variants in SP110 may influence macrophage signaling responses and apoptosis during M. tuberculosis infection, however further research is required to establish the mechanism by which SP110 influences immunity to tuberculosis infection. 25006821 2014
Entrez Id: 3431
Gene Symbol: SP110
SP110
0.100 Biomarker disease BEFREE Gene-based analysis also demonstrated that SP110 and MYBBP1A were each associated with TB (Pcor = 0.011 and 0.035, respectively). 23129390 2013
Entrez Id: 3431
Gene Symbol: SP110
SP110
0.100 Biomarker disease BEFREE In addition, a meta-analysis of the two previously TB associated SNPs revealed that these are not associated with TB, further confirming the lack of convincing evidence for SP110 to be implicated in TB susceptibility, as yet in humans. 22522001 2012
Entrez Id: 3431
Gene Symbol: SP110
SP110
0.100 Biomarker disease BEFREE Given the moderate strength of the results, the complexities of pulmonary and extra-pulmonary host genetic polymorphisms, gene-gene and gene-environment interactions, and the cross-species difference between human and mice, it would not be robust to remark that SP110 has no role in TB progress. 22691368 2012
Entrez Id: 3431
Gene Symbol: SP110
SP110
0.100 GeneticVariation disease BEFREE In this study we probed SP110 variants in pulmonary (PTB) and lymph node tuberculosis (LNTB) cases to explore their role in controlling susceptibility to Mycobacterium tuberculosis infection in north Indians. 21536091 2011
Entrez Id: 3431
Gene Symbol: SP110
SP110
0.100 GeneticVariation disease BEFREE This study was designed to investigate sequence variants of the SP110 gene in Chinese and test whether the SP110 gene is a susceptibility factor for tuberculosis. 21397050 2011
Entrez Id: 3431
Gene Symbol: SP110
SP110
0.100 AlteredExpression disease BEFREE Our results suggest that the up-regulation of Coronin-1 and Sp110, through a pathway that also includes TLR-2 up-regulation may be involved in the process of tuberculous infection in humans. 20718957 2010
Entrez Id: 3431
Gene Symbol: SP110
SP110
0.100 Biomarker disease BEFREE Real-time RT-PCR analysis confirmed up-regulation of a wide variety of genes including indoleamine 2,3 dioxygenase and Sp110 in M. tuberculosis and co-infected samples. 19520608 2009
Entrez Id: 3431
Gene Symbol: SP110
SP110
0.100 Biomarker disease BEFREE Further biochemical analysis of the Ipr1-mediated pathway will help delineate a mechanism of innate immunity that is especially important for control of tuberculosis progression in the lungs. 18727490 2008
Entrez Id: 3431
Gene Symbol: SP110
SP110
0.100 GeneticVariation disease BEFREE Our results indicate that common polymorphisms of the SP110 gene have no major effect on susceptibility to tuberculosis in this population. 17149599 2007
Entrez Id: 3431
Gene Symbol: SP110
SP110
0.100 GeneticVariation disease BEFREE Polymorphisms in the human homologue, SP110, have been investigated in various populations with only one study finding an association with TB susceptibility. 17287948 2007
Entrez Id: 3431
Gene Symbol: SP110
SP110
0.100 Biomarker disease BEFREE We have therefore examined the closest human homologue of Ipr1, SP110, for its ability to control susceptibility to M. tuberculosis infection in humans. 16803959 2006
Entrez Id: 3431
Gene Symbol: SP110
SP110
0.100 GeneticVariation disease BEFREE Based on the results obtained in this case-control study, the hypothesis that Sp110 variants and haplotypes might be associated with distinct phenotypes of human M tuberculosis infection is doubtful. 16816019 2006
Entrez Id: 3431
Gene Symbol: SP110
SP110
0.100 GeneticVariation disease LHGDN Based on the results obtained in this case-control study, the hypothesis that Sp110 variants and haplotypes might be associated with distinct phenotypes of human M tuberculosis infection is doubtful. 16816019 2006
Entrez Id: 3431
Gene Symbol: SP110
SP110
0.100 AlteredExpression disease BEFREE Expression of the Ipr1 transgene in the sst1 susceptible macrophages limits the multiplication not only of M. tuberculosis but also of Listeria monocytogenes and switches a cell death pathway of the infected macrophages from necrosis to apoptosis. 15815631 2005