Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3605
Gene Symbol: IL17A
IL17A
0.100 Biomarker disease BEFREE Since increased IL-17A levels are observed to be localized in the lung compartments (BAL and lymphocytes) in comparison to circulating levels, an inhalable PI3Kδ inhibitor, which is currently utilized for inflammatory airway diseases characterized by IL-17A over-secretion, may be a therapeutic option for active TB disease. 31736982 2019
Entrez Id: 3605
Gene Symbol: IL17A
IL17A
0.100 Biomarker disease BEFREE We further directly linked IL-17A as the responsible contributor of improved immunity against M.tb infection. 30778118 2019
Entrez Id: 3605
Gene Symbol: IL17A
IL17A
0.100 Biomarker disease BEFREE Accordingly, we examined the impact of individual versus combined neutralization of TNF-α and IL-17A in a mouse model of rheumatoid arthritis (collagen-induced arthritis) and the concomitant susceptibility to infections that are likely to manifest as side effects of blocking these cytokines (oral candidiasis or tuberculosis). 30745461 2019
Entrez Id: 3605
Gene Symbol: IL17A
IL17A
0.100 AlteredExpression disease BEFREE Moreover, <i>Mtb</i>-Ag-stimulated PBMCs from TB carrying the C allele produced the lowest levels of IFNG, the highest level of IL17A, and the minimum proliferation indexes as compared to TT TB, suggesting a relationship between the C allele and tuberculosis severity. 31616423 2019
Entrez Id: 3605
Gene Symbol: IL17A
IL17A
0.100 Biomarker disease BEFREE T helper 1 (Th1) cells producing interferon gamma (IFN-γ) and Th17 cells producing interleukin-17 (IL-17) play key roles in host protection against TB, whereas Th2 cells producing IL-4 and regulatory T cells (Tregs) facilitate TB disease progression by inhibiting protective Th1 and Th17 responses. 31481412 2019
Entrez Id: 3605
Gene Symbol: IL17A
IL17A
0.100 AlteredExpression disease BEFREE The plasma level of IL-17 in the MAC group was higher than in the TB and control groups. 29779777 2018
Entrez Id: 3605
Gene Symbol: IL17A
IL17A
0.100 Biomarker disease BEFREE It is concluded that 4-1BB has the potential to be used as a biomarker to identify MAIT cells with enhanced IFN-γ and IL-17 responses that might be associated with tuberculosis infection control. 29631725 2018
Entrez Id: 3605
Gene Symbol: IL17A
IL17A
0.100 AlteredExpression disease BEFREE IL-17 is expressed in TB patient granulomas and MMP-3 is expressed in adjacent pulmonary epithelial cells. 29210073 2018
Entrez Id: 3605
Gene Symbol: IL17A
IL17A
0.100 Biomarker disease BEFREE Our objective was to analyze, in an in vitro model, the influence of Infliximab on the granulomatous reactions and on the production of antigen-specific cytokines (TNF-α, IFN-γ, IL-12p40, IL-10 and IL-17) from beads sensitized with soluble Bacillus Calmette-Guérin (BCG) antigens cultured in the presence of peripheral blood mononuclear cells (PBMC) from TB patients. 29543912 2018
Entrez Id: 3605
Gene Symbol: IL17A
IL17A
0.100 Biomarker disease BEFREE Impairment in TNF, IL-1β, and IL-17 production upon stimulation with mycobacterial antigens may contribute to the increased susceptibility to M. tuberculosis infection observed in HTLV-1 infected individuals. 29523325 2018
Entrez Id: 3605
Gene Symbol: IL17A
IL17A
0.100 Biomarker disease BEFREE TB/Flu co-infected subjects had significantly higher IFN-γ+IL-17+CD4+ and IFN-γ+IL-17-CD8+ cells compared to TB mono-infected subjects. 30662443 2018
Entrez Id: 3605
Gene Symbol: IL17A
IL17A
0.100 Biomarker disease BEFREE As IL-27 limits optimal antimycobacterial protection by inhibiting IL-17A production, blocking of IL-27R-mediated signaling may represent a strategy for improving vaccination and host-directed therapy in tuberculosis. 29728641 2018
Entrez Id: 3605
Gene Symbol: IL17A
IL17A
0.100 Biomarker disease BEFREE IL-17 and IL-22 production in HIV+ individuals with latent and active tuberculosis. 29996789 2018
Entrez Id: 3605
Gene Symbol: IL17A
IL17A
0.100 GeneticVariation disease BEFREE Overall, our findings demonstrated that the AA genotype from the IL-17A rs2275913 SNP is positively associated with protection to active tuberculosis but related to higher disease severity in the Argentinean population. 28098168 2017
Entrez Id: 3605
Gene Symbol: IL17A
IL17A
0.100 Biomarker disease BEFREE IL17A augments autophagy in Mycobacterium tuberculosis-infected monocytes from patients with active tuberculosis in association with the severity of the disease. 28581888 2017
Entrez Id: 3605
Gene Symbol: IL17A
IL17A
0.100 Biomarker disease BEFREE There is evidence that IL-17 plays a role in the defense against tuberculosis. 28916742 2017
Entrez Id: 3605
Gene Symbol: IL17A
IL17A
0.100 GeneticVariation disease BEFREE Our results suggest that the TT genotype of IL-17A rs3748067 might be a risk factor for TB in Asians; the A allele, as well as the AG and AA+AG genotypes of the rs2275913 polymorphism, might be protective against TB in Caucasians. 29297452 2017
Entrez Id: 3605
Gene Symbol: IL17A
IL17A
0.100 Biomarker disease BEFREE These findings strongly support the development of a NE-TB vaccine as a novel, safe and effective, first-of-kind IL-17 inducing mucosal vaccine for potential use in humans. 28774560 2017
Entrez Id: 3605
Gene Symbol: IL17A
IL17A
0.100 Biomarker disease BEFREE Mice immunized with BCG expressing low levels of LTAK63 (rBCG-LTAK63<sub>lo</sub>) showed higher Th1 cytokines and IL-17 in the lungs, and when challenged intratracheally with Mycobacterium tuberculosis displayed a 2.0-3.0 log reduction in CFU as compared to wild type BCG. 28522873 2017
Entrez Id: 3605
Gene Symbol: IL17A
IL17A
0.100 Biomarker disease BEFREE However, IL-17 production by neutrophils contributed to collagen-induced arthritis development during MTB infection. 28821374 2017
Entrez Id: 3605
Gene Symbol: IL17A
IL17A
0.100 Biomarker disease BEFREE The present findings deepen our understanding of the role of IL-17 in MDR-TB and highlight the influence of the genetic background of the infecting M. tuberculosis strain on the ex-vivo Th17 response. 27681197 2017
Entrez Id: 3605
Gene Symbol: IL17A
IL17A
0.100 Biomarker disease BEFREE Metabolites from anaerobic bacterial fermentation may, therefore, increase TB susceptibility by suppressing IFN-γ and IL-17A production during the cellular immune response to M. tuberculosis. 28366509 2017
Entrez Id: 3605
Gene Symbol: IL17A
IL17A
0.100 Biomarker disease BEFREE The expression of IL-17 and IL-10 was significantly increased in active TB patients in comparison to that in latent TB or control groups (IL-17: 16.85±9.68 vs. 7.23±5.19 or 8.21±5.51pg/mL, p<0.05; IL-10: 28.70±11.27 vs. 20.25±8.57 or 13.94±9.00pg/mL, p<0.05). 27932286 2017
Entrez Id: 3605
Gene Symbol: IL17A
IL17A
0.100 Biomarker disease BEFREE Mucosal T-helper cells producing IFN-γ (Th1) and IL-17 (Th17) are important for protecting against tuberculosis (TB), but the mechanisms by which DCs generate antigen-specific T-helper responses during Mtb infection are not well defined. 28767735 2017
Entrez Id: 3605
Gene Symbol: IL17A
IL17A
0.100 Biomarker disease BEFREE However, there are very little data on the role of IL-17 in human studies of tuberculosis (TB). 29075255 2017