Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 9271
Gene Symbol: PIWIL1
PIWIL1
0.010 Biomarker disease BEFREE <b>Conclusion:</b> Findings demonstrated that the PIWI-piRNA pathway is active in human peripheral blood, where it may represent a new player in the PTB pathogenesis. 31755303 2019
Entrez Id: 143689
Gene Symbol: PIWIL4
PIWIL4
0.010 Biomarker disease BEFREE <b>Conclusion:</b> Findings demonstrated that the PIWI-piRNA pathway is active in human peripheral blood, where it may represent a new player in the PTB pathogenesis. 31755303 2019
Entrez Id: 7097
Gene Symbol: TLR2
TLR2
0.100 GeneticVariation disease BEFREE (3) Stratified by sample type, TLR2 Arg753Gln polymorphism is associated with increased PTB risk, but not with EPTB. 30733958 2019
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.100 GeneticVariation disease BEFREE -592 and -1082 interleukin-10 polymorphisms in pulmonary tuberculosis with type 2 diabetes. 23768819 2013
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.090 Biomarker disease BEFREE 1,25(OH)2D3 significantly suppressed all the CFA induced pro-inflammatory cytokines (p<0.05) studied except IL-1β in both HCs and PTB patients. 25194676 2014
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.100 AlteredExpression disease BEFREE 247 HIV-TB (124 HIV-pulmonary TB, 123 HIV-extra pulmonary TB), 126 HIV positive individuals without tuberculosis and 129 healthy subjects (HS) were included to measure plasma levels of IFN-γ and TNF-α by sandwich ELISA and One way ANOVA statistical analysis was carried out among the groups. 27521485 2016
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.100 AlteredExpression disease BEFREE 247 HIV-TB (124 HIV-pulmonary TB, 123 HIV-extra pulmonary TB), 126 HIV positive individuals without tuberculosis and 129 healthy subjects (HS) were included to measure plasma levels of IFN-γ and TNF-α by sandwich ELISA and One way ANOVA statistical analysis was carried out among the groups. 27521485 2016
Entrez Id: 9815
Gene Symbol: GIT2
GIT2
0.020 Biomarker disease BEFREE 890 sputum smear positive Cat II PTB patients were randomized to receive either six intra-dermal injections (2 + 4) of heat-killed MIP at a dose of 5 × 10<sup>8</sup> bacilli or placebo once in 2 weeks for 2 months. 28611374 2017
Entrez Id: 56302
Gene Symbol: TRPV5
TRPV5
0.020 Biomarker disease BEFREE 890 sputum smear positive Cat II PTB patients were randomized to receive either six intra-dermal injections (2 + 4) of heat-killed MIP at a dose of 5 × 10<sup>8</sup> bacilli or placebo once in 2 weeks for 2 months. 28611374 2017
Entrez Id: 6542
Gene Symbol: SLC7A2
SLC7A2
0.020 Biomarker disease BEFREE 890 sputum smear positive Cat II PTB patients were randomized to receive either six intra-dermal injections (2 + 4) of heat-killed MIP at a dose of 5 × 10<sup>8</sup> bacilli or placebo once in 2 weeks for 2 months. 28611374 2017
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.100 GeneticVariation disease BEFREE : HLA, IFNG, TNF, NRPAM1, IL10) variants and the development of active pulmonary TB. 27101784 2016
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.100 GeneticVariation disease BEFREE : HLA, IFNG, TNF, NRPAM1, IL10) variants and the development of active pulmonary TB. 27101784 2016
Entrez Id: 260431
Gene Symbol: COPD
COPD
0.030 Biomarker disease BEFREE Pulmonary tuberculosis (PTB) is a risk factor for COPD, but the clinical characteristics and the chest imaging features (emphysema and bronchiectasis) of COPD with previous PTB have not been studied well. 29416328 2018
Entrez Id: 5725
Gene Symbol: PTBP1
PTBP1
0.090 Biomarker disease BEFREE Pulmonary tuberculosis (PTB,both smear positive and smear negative) is an airborne infectious disease of major public health concern in China and other parts of the world where PTB endemicity is reported. 30115099 2018
Entrez Id: 58155
Gene Symbol: PTBP2
PTBP2
0.090 Biomarker disease BEFREE Pulmonary tuberculosis (PTB,both smear positive and smear negative) is an airborne infectious disease of major public health concern in China and other parts of the world where PTB endemicity is reported. 30115099 2018
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.100 Biomarker disease BEFREE HLA-DRB1*1501 and DQB1*0601 predisposed to sputum positive pulmonary tuberculosis, and DPB1*04 was preventive and epistatic to this risk. 10707259 1999
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.100 Biomarker disease BEFREE HLA DRB1*02 and its subtypes predispose individuals for a far-advanced sputum-positive pulmonary tuberculosis transcending ethnic boundaries. 11500439 2001
Entrez Id: 129831
Gene Symbol: RBM45
RBM45
0.100 Biomarker disease BEFREE DRB1 *1501 and *1502 positive as well as negative ATB patients showed a higher antibody titre as compared to controls and ITB patients. 11558319 2001
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.100 Biomarker disease BEFREE DRB1 *1501 and *1502 positive as well as negative ATB patients showed a higher antibody titre as compared to controls and ITB patients. 11558319 2001
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.100 GeneticVariation disease BEFREE Interferon-gamma and interleukin-10 gene polymorphisms in pulmonary tuberculosis. 12531774 2003
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.100 GeneticVariation disease BEFREE HLA DRB1 homozygosity among HIV-positive subjects was associated with reduced risk of developing pulmonary TB but increased risk of rapid progression to pleural effusion TB. 14999612 2004
Entrez Id: 92105
Gene Symbol: INTS4
INTS4
0.070 GeneticVariation disease BEFREE INT4-D543N-3'UTR haplotypes showed an association with pulmonary TB (P=0.03). 16461017 2006
Entrez Id: 7473
Gene Symbol: WNT3
WNT3
0.070 GeneticVariation disease BEFREE INT4-D543N-3'UTR haplotypes showed an association with pulmonary TB (P=0.03). 16461017 2006
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.100 Biomarker disease BEFREE Interferon gamma +874A and IL-4 -590T promoter polymorphisms were studied in 129 pulmonary tuberculosis (PTB) patients and 127 normal healthy subjects (NHS) and were associated with culture filtrate and live Mycobacterium tuberculosis induced IFNgamma and IL-4 production in peripheral blood mononuclear cells (PBMCs). 17159260 2006
Entrez Id: 3431
Gene Symbol: SP110
SP110
0.080 GeneticVariation disease BEFREE SP110 polymorphisms are not associated with pulmonary tuberculosis in a South African population. 17287948 2007