Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3565
Gene Symbol: IL4
IL4
0.100 AlteredExpression disease BEFREE Finally, following ATT, the plasma levels of IL-4, IL-5 and IL-10 were significantly decreased, while the plasma levels of IL-13 and IL-37 were significantly increased in PTB individuals. 31811994 2020
Entrez Id: 3565
Gene Symbol: IL4
IL4
0.100 AlteredExpression disease BEFREE IFN-γ (P < 0.001), TNF-α (P = 0.004), IL-2 (P = 0.004) and IL-4 (P = 0.009) median levels were elevated in PTB culture-positive (AFB microscopy smear negative) as compared to PTB culture-negative (AFB microscopy smear negative) participants. 30814543 2019
Entrez Id: 3565
Gene Symbol: IL4
IL4
0.100 AlteredExpression disease BEFREE However, the levels of IL-4 and TNF-α in the sera of patients from the PTB group did not show a significant correlation with those measured in the healthy donor group. 31012357 2019
Entrez Id: 3565
Gene Symbol: IL4
IL4
0.100 Biomarker disease BEFREE We showed that HIV infection significantly reduced the proportion of Th2 (interleukin 4 [IL-4]/IL-5/IL-13) producing <i>M. tuberculosis</i>-specific CD4 T cells and IL-2-producing <i>M. tuberculosis</i>-specific CD4 and CD8 T cells in individuals with LTBI or PTB (<i>P < </i>0.05). 30541853 2019
Entrez Id: 3565
Gene Symbol: IL4
IL4
0.100 AlteredExpression disease BEFREE Regulatory T-cell (Treg) and Th1 cytokine levels were evaluated using flow cytometry.In blood, but not BAL, IL-4 mRNA levels (p=0.02) and the IL-4/IFN-γ ratio (p=0.01) was higher in TB <i>versus</i> LTBI. hrIL-4 reduced mycobacterial containment in infected macrophages (p<0.008) in a dose-dependent manner and was associated with an increase in Tregs (p<0.001), but decreased CD4<sup>+</sup>Th1 cytokine levels (CD4<sup>+</sup>IFN-γ<sup>+</sup> p<0.001; CD4<sup>+</sup>TNFα<sup>+</sup> p=0.01). 31097521 2019
Entrez Id: 3565
Gene Symbol: IL4
IL4
0.100 AlteredExpression disease BEFREE The serum levels of inflammatory factors interleukin (IL)-1, IL-6, IL-10, IL-12, and IL-4 were upregulated in patients with pulmonary tuberculosis in ICU. 29456674 2018
Entrez Id: 3565
Gene Symbol: IL4
IL4
0.100 AlteredExpression disease BEFREE At baseline, IL-1, IL-2, IL-12P70, and soluble CD62E levels were significantly higher in PTB patients than those in the healthy controls (p < 0.05); IL-4, IL-5, IL-7, IL-8, IL-10, IL-17, IL-21, soluble CD54, MIG, and TGF-β levels in PTB patients were significantly lower than those in the healthy controls (p < 0.05), of which TGF-β, IL-7, IL-8, IL-10, soluble CD54, and MIG were most notably (p < 0.0005). 29554572 2018
Entrez Id: 3565
Gene Symbol: IL4
IL4
0.100 GeneticVariation disease BEFREE Association of <i>IL4, IL6</i>, and <i>IL10</i> polymorphisms with pulmonary tuberculosis in a Tibetan Chinese population. 29662655 2018
Entrez Id: 3565
Gene Symbol: IL4
IL4
0.100 Biomarker disease BEFREE We also predicted Rv2204c specific CD8<sup>+</sup> T cells secreting IL-10 or IL-4 showed maximum differentiation between LTBI and PTB. 29325881 2018
Entrez Id: 3565
Gene Symbol: IL4
IL4
0.100 GeneticVariation disease BEFREE The aim of this study was to evaluate the association between previously reported SNPs IL2-330 T>G (rs2069762); IL4-590 C>T (rs2243250); IL6-174 G>C (rs1800795); IL10-592 A>C (rs1800872); IL10-1082 G>A (rs1800896); IL17A -692 C>T (rs8193036); IL17A -197 G>A (rs2275913); TNF -238 G>A (rs361525); TNF -308 G>A (rs1800629) and IFNG +874 T>A (rs2430561) and pulmonary TB (PTB) susceptibility. 26840977 2016
Entrez Id: 3565
Gene Symbol: IL4
IL4
0.100 GeneticVariation disease BEFREE Using multiple corrections, significant overall risk against PTB was observed at seven loci which included variants in IFNG at rs1861493 and rs1861494; IL1RA at rs4252019, IL4 variant rs2070874, IL12 variants rs3212220, rs2853694 and TNFB variant rs1041981. 22771610 2012
Entrez Id: 3565
Gene Symbol: IL4
IL4
0.100 Biomarker disease BEFREE The Th1 cytokine interferon-gamma (IFN-γ) and Th2 cytokines interleukin 4 (IL-4) and interleukin 5 (IL-5) in 62 pulmonary tuberculosis (TB) patients (40 Warao indigenous patients [WP] and 22 Creole non-indigenous patients [CP]) and 24 healthy controls (12 Warao indigenous controls [WC] and 12 Creole non-indigenous controls [CC]) at 24 and 48 hours in response to purified protein derivative (PPD) from Mycobacterium tuberculosis. 20650294 2010
Entrez Id: 3565
Gene Symbol: IL4
IL4
0.100 AlteredExpression disease BEFREE In conclusion, the ratio of IL-4delta2 to IL-4 mRNA expression may play a key role in disease severity for patients with pulmonary tuberculosis. 17961771 2007
Entrez Id: 3565
Gene Symbol: IL4
IL4
0.100 Biomarker disease BEFREE To evaluate this the stability of IL-4 and IL-4delta2 mRNA after the addition of actinomycin-D, was evaluated in whole blood from subjects with pulmonary TB and uninfected healthy volunteers. 17196882 2007
Entrez Id: 3565
Gene Symbol: IL4
IL4
0.100 AlteredExpression disease LHGDN In conclusion, the ratio of IL-4delta2 to IL-4 mRNA expression may play a key role in disease severity for patients with pulmonary tuberculosis. 17961771 2007
Entrez Id: 3565
Gene Symbol: IL4
IL4
0.100 GeneticVariation disease BEFREE The higher frequency of IL-4 'CT' genotype in PTB suggests a possible association of IL-4 -590T promoter polymorphism with susceptibility to tuberculosis, and the 'CC' genotype may be associated with protection. 17159260 2006
Entrez Id: 3565
Gene Symbol: IL4
IL4
0.100 Biomarker disease BEFREE The basis for this observation was studied by examining the Th1 (interleukin 2 [IL-2] and gamma interferon [IFN-gamma])- and Th2 (IL-10 and IL-4)-type cytokines produced in response to the 30-kDa Ag by peripheral blood mononuclear cells (PBMC) from patients with active pulmonary TB (n = 7) and from HHC who were tuberculin (purified protein derivative) skin test positive (n = 12). 9423855 1998